Toenail mercury Levels are associated with amyotrophic lateral sclerosis risk

Angeline S. Andrew, Celia Y. Chen, Tracie A. Caller, Rup Tandan, Patricia L. Henegan, Brian P. Jackson, Brenda P. Hall, Walter G Bradley, Elijah W. Stommel

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Introduction: Mercury is a neurotoxic metal that is potentially a risk factor for amyotrophic lateral sclerosis (ALS). Consumption of methylmercury contaminated fish is the primary source of US population exposure to mercury. Methods: We used inductively coupled plasma mass spectrometry to measure levels of mercury in toenail samples from patients with ALS (n = 46) and from controls (n = 66) as a biomarker of mercury exposure. Results: Patients with ALS had higher toenail mercury levels (odds ratio 2.49, 95% confidence interval 1.18–5.80, P = 0.024) compared with controls, adjusted for age and sex. We also estimated the amount of mercury consumed from finfish and shellfish and found toenail mercury levels elevated overall among patients with ALS and controls in the top quartile for consumption (P = 0.018). Discussion: Biomarker data show that ALS is associated with increased with mercury levels, which were related to estimated methylmercury intake via fish. Replication of these associations in additional populations is warranted. Muscle Nerve 58: 36–41, 2018.

Original languageEnglish (US)
Pages (from-to)36-41
Number of pages6
JournalMuscle and Nerve
Volume58
Issue number1
DOIs
StatePublished - Jul 1 2018

Fingerprint

Amyotrophic Lateral Sclerosis
Nails
Mercury
Fishes
Biomarkers
Shellfish
Population
Mass Spectrometry
Metals
Odds Ratio
Confidence Intervals
Muscles

Keywords

  • amyotrophic lateral sclerosis
  • case-control studies
  • fish
  • mercury
  • methylmercury
  • neuromuscular disease
  • toenail
  • toxicology

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Andrew, A. S., Chen, C. Y., Caller, T. A., Tandan, R., Henegan, P. L., Jackson, B. P., ... Stommel, E. W. (2018). Toenail mercury Levels are associated with amyotrophic lateral sclerosis risk. Muscle and Nerve, 58(1), 36-41. https://doi.org/10.1002/mus.26055

Toenail mercury Levels are associated with amyotrophic lateral sclerosis risk. / Andrew, Angeline S.; Chen, Celia Y.; Caller, Tracie A.; Tandan, Rup; Henegan, Patricia L.; Jackson, Brian P.; Hall, Brenda P.; Bradley, Walter G; Stommel, Elijah W.

In: Muscle and Nerve, Vol. 58, No. 1, 01.07.2018, p. 36-41.

Research output: Contribution to journalArticle

Andrew, AS, Chen, CY, Caller, TA, Tandan, R, Henegan, PL, Jackson, BP, Hall, BP, Bradley, WG & Stommel, EW 2018, 'Toenail mercury Levels are associated with amyotrophic lateral sclerosis risk', Muscle and Nerve, vol. 58, no. 1, pp. 36-41. https://doi.org/10.1002/mus.26055
Andrew AS, Chen CY, Caller TA, Tandan R, Henegan PL, Jackson BP et al. Toenail mercury Levels are associated with amyotrophic lateral sclerosis risk. Muscle and Nerve. 2018 Jul 1;58(1):36-41. https://doi.org/10.1002/mus.26055
Andrew, Angeline S. ; Chen, Celia Y. ; Caller, Tracie A. ; Tandan, Rup ; Henegan, Patricia L. ; Jackson, Brian P. ; Hall, Brenda P. ; Bradley, Walter G ; Stommel, Elijah W. / Toenail mercury Levels are associated with amyotrophic lateral sclerosis risk. In: Muscle and Nerve. 2018 ; Vol. 58, No. 1. pp. 36-41.
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