Tmem16b is specifically expressed in the cilia of olfactory sensory neurons

Sebastian Rasche, Bastian Toetter, Jenny Adler, Astrid Tschapek, Julia F. Doerner, Stefan Kurtenbach, Hanns Hatt, Helmut Meyer, Bettina Warscheid, Eva M. Neuhaus

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Calcium-activated chloride channels (CaCCs) are involved in many physiological processes, including sensory signal transduction, but only little is known to date about their structure and function. We performed a proteome analysis of the olfactory epithelium (OE) membrane proteome and identified so far uncharacterized membrane proteins as candidate channels. One of the most abundant membrane proteins in olfactory sensory neurons (OSNs) was Tmem16b, a member of a recently identified family of CaCCs. In addition to former studies performed on Tmem16b, we show here that Tmem16b expression is highly specific for the OE, in contrast to the closely related Tmem16a, which shows a broad expression pattern in secretory epithelial cells. Native Tmem16b is localized in the cilia of the OSNs, which is in agreement with previous electrophysiological recordings.

Original languageEnglish (US)
Pages (from-to)239-245
Number of pages7
JournalChemical senses
Volume35
Issue number3
DOIs
StatePublished - Jan 25 2010
Externally publishedYes

Keywords

  • Chloride channel
  • Proteomics
  • Signal transduction
  • Tmem16b

ASJC Scopus subject areas

  • Physiology
  • Sensory Systems
  • Physiology (medical)
  • Behavioral Neuroscience

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