TLR signaling: A link between gut microflora, colorectal inflammation and tumorigenesis

Rebeca Santaolalla; Daniel A. Sussman; Maria T. Abreu

doi:10.1016/j.ddmec.2012.02.002

TLR signaling: A link between gut microflora, colorectal inflammation and tumorigenesis

Rebeca Santaolalla, Daniel A. Sussman, Maria T. Abreu

Medicine

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

A growing body of evidence supports the role of tolllike receptor (TLR) signaling in the intestinal mucosa and its role in inflammation and tumorigenesis. Patients with chronic intestinal inflammation, as is the case with inflammatory bowel disease (IBD), and a subset of patients with inflammatory and sporadic colorectal neoplasia, have increased expression of TLRs, especially TLR4, on colonic epithelial cells. Mouse models of colitis and cancer are useful to understand the role of TLRs and bacteria in the development of colon cancer. Clear differences in bacterial colonization patterns are noted between normal and dysplastic colonic mucosa. TLRs offer a potential prognostic and therapeutic target, serving as the link between bacterial ligands and epithelial inflammation.

Original language	English (US)
Pages (from-to)	e57-e62
Journal	Drug Discovery Today: Disease Mechanisms
Volume	8
Issue number	3-4
DOIs	https://doi.org/10.1016/j.ddmec.2012.02.002
State	Published - Jan 1 2011

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ddmec.2012.02.002

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title = "TLR signaling: A link between gut microflora, colorectal inflammation and tumorigenesis",

abstract = "A growing body of evidence supports the role of tolllike receptor (TLR) signaling in the intestinal mucosa and its role in inflammation and tumorigenesis. Patients with chronic intestinal inflammation, as is the case with inflammatory bowel disease (IBD), and a subset of patients with inflammatory and sporadic colorectal neoplasia, have increased expression of TLRs, especially TLR4, on colonic epithelial cells. Mouse models of colitis and cancer are useful to understand the role of TLRs and bacteria in the development of colon cancer. Clear differences in bacterial colonization patterns are noted between normal and dysplastic colonic mucosa. TLRs offer a potential prognostic and therapeutic target, serving as the link between bacterial ligands and epithelial inflammation.",

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T2 - A link between gut microflora, colorectal inflammation and tumorigenesis

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AU - Sussman, Daniel A.

AU - Abreu, Maria T.

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Y1 - 2011/1/1

N2 - A growing body of evidence supports the role of tolllike receptor (TLR) signaling in the intestinal mucosa and its role in inflammation and tumorigenesis. Patients with chronic intestinal inflammation, as is the case with inflammatory bowel disease (IBD), and a subset of patients with inflammatory and sporadic colorectal neoplasia, have increased expression of TLRs, especially TLR4, on colonic epithelial cells. Mouse models of colitis and cancer are useful to understand the role of TLRs and bacteria in the development of colon cancer. Clear differences in bacterial colonization patterns are noted between normal and dysplastic colonic mucosa. TLRs offer a potential prognostic and therapeutic target, serving as the link between bacterial ligands and epithelial inflammation.

AB - A growing body of evidence supports the role of tolllike receptor (TLR) signaling in the intestinal mucosa and its role in inflammation and tumorigenesis. Patients with chronic intestinal inflammation, as is the case with inflammatory bowel disease (IBD), and a subset of patients with inflammatory and sporadic colorectal neoplasia, have increased expression of TLRs, especially TLR4, on colonic epithelial cells. Mouse models of colitis and cancer are useful to understand the role of TLRs and bacteria in the development of colon cancer. Clear differences in bacterial colonization patterns are noted between normal and dysplastic colonic mucosa. TLRs offer a potential prognostic and therapeutic target, serving as the link between bacterial ligands and epithelial inflammation.

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JO - Drug Discovery Today: Disease Mechanisms

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IS - 3-4

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TLR signaling: A link between gut microflora, colorectal inflammation and tumorigenesis

Abstract

ASJC Scopus subject areas

UN SDGs

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