TLR signaling: A link between gut microflora, colorectal inflammation and tumorigenesis

Rebeca Santaolalla, Daniel A. Sussman, Maria T. Abreu

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

A growing body of evidence supports the role of tolllike receptor (TLR) signaling in the intestinal mucosa and its role in inflammation and tumorigenesis. Patients with chronic intestinal inflammation, as is the case with inflammatory bowel disease (IBD), and a subset of patients with inflammatory and sporadic colorectal neoplasia, have increased expression of TLRs, especially TLR4, on colonic epithelial cells. Mouse models of colitis and cancer are useful to understand the role of TLRs and bacteria in the development of colon cancer. Clear differences in bacterial colonization patterns are noted between normal and dysplastic colonic mucosa. TLRs offer a potential prognostic and therapeutic target, serving as the link between bacterial ligands and epithelial inflammation.

Original languageEnglish (US)
Pages (from-to)e57-e62
JournalDrug Discovery Today: Disease Mechanisms
Volume8
Issue number3-4
DOIs
StatePublished - Jan 1 2011

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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