Tissue-specific targeting of retroviral vectors via ligand-receptor interactions

Noriyuki Kasahara, Andrée M. Dozy, Yuet Wai Kan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The development of retroviral vectors that target specific cell types could have important implications for the design of gene therapy strategies. A chimeric protein containing the polypeptide hormone erythropoietin and part of the env protein of ecotropic Moloney murine leukemia virus was engineered into the virus. This murine virus became several times more infectious for murine cells bearing the erythropoietin receptor, and it also became infectious for human cells bearing the erythropoietin receptor. This type of tissue-specific targeting by means of ligand-receptor interactions may have broad implications to a variety of gene delivery systems.

Original languageEnglish (US)
Pages (from-to)227-234
Number of pages8
JournalAdvanced Drug Delivery Reviews
Volume17
Issue number3
DOIs
StatePublished - Dec 5 1995
Externally publishedYes

Fingerprint

Erythropoietin Receptors
Ligands
env Gene Products
Viruses
Moloney murine leukemia virus
Gene Transfer Techniques
Peptide Hormones
Erythropoietin
Genetic Therapy
Proteins

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Tissue-specific targeting of retroviral vectors via ligand-receptor interactions. / Kasahara, Noriyuki; Dozy, Andrée M.; Kan, Yuet Wai.

In: Advanced Drug Delivery Reviews, Vol. 17, No. 3, 05.12.1995, p. 227-234.

Research output: Contribution to journalArticle

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