Abstract
The development of retroviral vectors that target specific cell types could have important implications for the design of gene therapy strategies. A chimeric protein containing the polypeptide hormone erythropoietin and part of the env protein of ecotropic Moloney murine leukemia virus was engineered into the virus. This murine virus became several times more infectious for murine cells bearing the erythropoietin receptor, and it also became infectious for human cells bearing the erythropoietin receptor. This type of tissue-specific targeting by means of ligand-receptor interactions may have broad implications to a variety of gene delivery systems.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 227-234 |
| Number of pages | 8 |
| Journal | Advanced Drug Delivery Reviews |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 5 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Tissue-specific targeting of retroviral vectors via ligand-receptor interactions. / Kasahara, Noriyuki; Dozy, Andrée M.; Kan, Yuet Wai.
In: Advanced Drug Delivery Reviews, Vol. 17, No. 3, 05.12.1995, p. 227-234.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tissue-specific targeting of retroviral vectors via ligand-receptor interactions
AU - Kasahara, Noriyuki
AU - Dozy, Andrée M.
AU - Kan, Yuet Wai
PY - 1995/12/5
Y1 - 1995/12/5
N2 - The development of retroviral vectors that target specific cell types could have important implications for the design of gene therapy strategies. A chimeric protein containing the polypeptide hormone erythropoietin and part of the env protein of ecotropic Moloney murine leukemia virus was engineered into the virus. This murine virus became several times more infectious for murine cells bearing the erythropoietin receptor, and it also became infectious for human cells bearing the erythropoietin receptor. This type of tissue-specific targeting by means of ligand-receptor interactions may have broad implications to a variety of gene delivery systems.
AB - The development of retroviral vectors that target specific cell types could have important implications for the design of gene therapy strategies. A chimeric protein containing the polypeptide hormone erythropoietin and part of the env protein of ecotropic Moloney murine leukemia virus was engineered into the virus. This murine virus became several times more infectious for murine cells bearing the erythropoietin receptor, and it also became infectious for human cells bearing the erythropoietin receptor. This type of tissue-specific targeting by means of ligand-receptor interactions may have broad implications to a variety of gene delivery systems.
UR - http://www.scopus.com/inward/record.url?scp=0029637137&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029637137&partnerID=8YFLogxK
U2 - 10.1016/0169-409X(95)00055-C
DO - 10.1016/0169-409X(95)00055-C
M3 - Article
AN - SCOPUS:0029637137
VL - 17
SP - 227
EP - 234
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
IS - 3
ER -