@article{3fa7c34f4dd04755a78e166126600f5f,
title = "Tissue-specific targeting of retroviral vectors via ligand-receptor interactions",
abstract = "The development of retroviral vectors that target specific cell types could have important implications for the design of gene therapy strategies. A chimeric protein containing the polypeptide hormone erythropoietin and part of the env protein of ecotropic Moloney murine leukemia virus was engineered into the virus. This murine virus became several times more infectious for murine cells bearing the erythropoietin receptor, and it also became infectious for human cells bearing the erythropoietin receptor. This type of tissue-specific targeting by means of ligand-receptor interactions may have broad implications to a variety of gene delivery systems.",
author = "Noriyuki Kasahara and Dozy, {Andr{\'e}e M.} and Kan, {Yuet Wai}",
note = "Funding Information: We thank J. Chang for help in retrovirusw ork and T. Reudelhuber,D . Gardner, K. Yamamoto and J.A.T. Young for stimulatingd iscussionsa nd helpful advice. Plasmids containing MO-MuLV genesw ere generouslyp rovided by A. Bank and D. Markowitz. A plasmidc ontainingE PO cDNA sequencesw as generouslyp rovided by K. Shannon. Plasmidsc ontainingt he murine and human EPO receptor cDNAs were generouslyp rovided by A. D{\textquoteright}Andrea. Polyclonal antiserumt o EPO no. 8C295 was generouslyp rovided by J. Egrie. Supported in part by NIH grants no. HL 20985 to the Northern California ComprehensiveS ickle Cell Center and no. AM16666 (to Y.W.K., who is an investigatoro f the Howard Hughes Medical Institute).",
year = "1995",
month = dec,
day = "5",
doi = "10.1016/0169-409X(95)00055-C",
language = "English (US)",
volume = "17",
pages = "227--234",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier",
number = "3",
}