Tissue-specific targeting of retroviral vectors through ligand-receptor interactions

Noriyuki Kasahara, Andrée M. Dozy, Yuet Wai Kan

Research output: Contribution to journalArticle

372 Scopus citations

Abstract

The development of retroviral vectors that target specific cell types could have important implications for the design of gene therapy strategies. A chimeric protein containing the polypeptide hormone erythropoietin and part of the env protein of ecotropic Moloney murine leukemia virus was engineered into the virus. This murine virus became several times more infectious for murine cells bearing the erythropoietin receptor, and it also became infectious for human cells bearing the erythropoietin receptor. This type of tissue-specific targeting by means of ligand-receptor interactions may have broad applications to a variety of gene delivery systems.

Original languageEnglish (US)
Pages (from-to)1373-1376
Number of pages4
JournalScience
Volume266
Issue number5189
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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ASJC Scopus subject areas

  • General

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