Tissue-specific targeting of retroviral vectors through ligand-receptor interactions

Noriyuki Kasahara, A. M. Dozy, Y. W. Kan

Research output: Contribution to journalArticle

370 Citations (Scopus)

Abstract

The development of retroviral vectors that target specific cell types could have important implications for the design of gene therapy strategies. A chimeric protein containing the polypeptide hormone erythropoietin and part of the env protein of ecotropic Moloney murine leukemia virus was engineered into the virus. This murine virus became several times more infectious for murine cells bearing the erythropoietin receptor, and it also became infectious for human cells bearing the erythropoietin receptor. This type of tissue-specific targeting by means of ligand-receptor interactions may have broad applications to a variety of gene delivery systems.

Original languageEnglish (US)
Pages (from-to)1373-1376
Number of pages4
JournalScience
Volume266
Issue number5189
StatePublished - 1994
Externally publishedYes

Fingerprint

Erythropoietin Receptors
Ligands
env Gene Products
Viruses
Moloney murine leukemia virus
Gene Transfer Techniques
Peptide Hormones
Erythropoietin
Genetic Therapy
Proteins

ASJC Scopus subject areas

  • General

Cite this

Tissue-specific targeting of retroviral vectors through ligand-receptor interactions. / Kasahara, Noriyuki; Dozy, A. M.; Kan, Y. W.

In: Science, Vol. 266, No. 5189, 1994, p. 1373-1376.

Research output: Contribution to journalArticle

Kasahara, Noriyuki ; Dozy, A. M. ; Kan, Y. W. / Tissue-specific targeting of retroviral vectors through ligand-receptor interactions. In: Science. 1994 ; Vol. 266, No. 5189. pp. 1373-1376.
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