Tissue response to intraperitoneal implants of polyethylene oxide-modified polyethylene terephthalate

Neil P. Desai, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

29 Scopus citations


Polyethylene terephthalate films surface modified with polyethylene oxide of mol wt 18 500 g/mol (18.5 k) by a previously described technique, were implanted in the peritoneal cavity of mice, along with their respective untreated controls, for periods of 1-28 d. The implants were retrieved and examined for tissue reactivity and cellular adherence. The control polyethylene terephthalate surfaces showed an initial inflammatory reaction followed by an extensive fibrotic response with a mean thickness of 60 μm at 28 d. By contrast, polyethylene oxide-modified polyethylene terephthalate showed only a mild inflammatory response and no fibrotic encapsulation throughout the implantation period; at 28 d a cellular monolayer was observed. Apparently either the polyethylene oxide-modified surface was stimulating less inflammation, which was in turn stimulating less fibroblastic overgrowth, or the cellular adhesion to the polyethylene oxide-modified surface was too weak to support cellular multilayers.

Original languageEnglish (US)
Pages (from-to)505-510
Number of pages6
Issue number8
StatePublished - 1992



  • adhesion
  • Polyethylene oxide
  • polyethylene terephthalate
  • surface treatment

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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