Tissue Factor Coagulation Pathway: A New Therapeutic Target in Atherothrombosis

Juan F. Viles-Gonzalez, Sunil X. Anand, M. Urooj Zafar, Valentin Fuster, Juan J. Badimon

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Atherothrombosis, defined as atherosclerotic lesion disruption with superimposed thrombus formation, is the major cause of acute coronary syndromes and cardiovascular deaths. It is the leading cause of morbidity and mortality in the industrialized world. Plaque composition, rather than luminal stenosis, is recognized as the major determinant of this disease. Since tissue factor is found within atheroma and also in the bloodstream of atherosclerotic patients, it likely plays a key role in determining both plaque and blood thrombogenicity. Ongoing clinical and preclinical studies are evaluating the therapeutic possibilities of specific inhibition of the tissue factor pathway. Here, we will review the role of tissue factor in atherothrombosis and therapeutic applications.

Original languageEnglish (US)
Pages (from-to)669-676
Number of pages8
JournalJournal of Cardiovascular Pharmacology
Volume43
Issue number5
DOIs
StatePublished - May 1 2004

Keywords

  • Antithrombotics
  • Atherothrombosis
  • Factor x inhibitors
  • Thrombin inhibitors
  • Tissue factor

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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