Abstract
Background: Patients suffering from diseased and injured organs may be treated with transplanted organs. However, there is a severe shortage of donor organs which is worsening yearly due to the aging population. Scientists in the field of tissue engineering apply the principles of cell transplantation, materials science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Both therapeutic cloning (nucleus from a donor cell is transferred into an enucleated oocyte), and parthenogenesis (oocyte is activated and stimulated to divide), permit extraction of pluripotent embryonic stem cells, and offer a potentially limitless source of cells for tissue engineering applications. The stem cell field is also advancing rapidly, opening new options for therapy. The present article reviews recent progress in tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.
| Original language | English |
|---|---|
| Journal | Journal of Experimental and Clinical Assisted Reproduction |
| Volume | 1 |
| DOIs | |
| State | Published - Dec 8 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Tissue engineering, stem cells, cloning, and parthenogenesis : New paradigms for therapy. / Hipp, Jason; Atala, Anthony.
In: Journal of Experimental and Clinical Assisted Reproduction, Vol. 1, 08.12.2004.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tissue engineering, stem cells, cloning, and parthenogenesis
T2 - New paradigms for therapy
AU - Hipp, Jason
AU - Atala, Anthony
PY - 2004/12/8
Y1 - 2004/12/8
N2 - Background: Patients suffering from diseased and injured organs may be treated with transplanted organs. However, there is a severe shortage of donor organs which is worsening yearly due to the aging population. Scientists in the field of tissue engineering apply the principles of cell transplantation, materials science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Both therapeutic cloning (nucleus from a donor cell is transferred into an enucleated oocyte), and parthenogenesis (oocyte is activated and stimulated to divide), permit extraction of pluripotent embryonic stem cells, and offer a potentially limitless source of cells for tissue engineering applications. The stem cell field is also advancing rapidly, opening new options for therapy. The present article reviews recent progress in tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.
AB - Background: Patients suffering from diseased and injured organs may be treated with transplanted organs. However, there is a severe shortage of donor organs which is worsening yearly due to the aging population. Scientists in the field of tissue engineering apply the principles of cell transplantation, materials science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Both therapeutic cloning (nucleus from a donor cell is transferred into an enucleated oocyte), and parthenogenesis (oocyte is activated and stimulated to divide), permit extraction of pluripotent embryonic stem cells, and offer a potentially limitless source of cells for tissue engineering applications. The stem cell field is also advancing rapidly, opening new options for therapy. The present article reviews recent progress in tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.
UR - http://www.scopus.com/inward/record.url?scp=15744400422&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=15744400422&partnerID=8YFLogxK
U2 - 10.1186/1743-1050-1-3
DO - 10.1186/1743-1050-1-3
M3 - Article
AN - SCOPUS:15744400422
VL - 1
JO - Journal of Experimental and Clinical Assisted Reproduction
JF - Journal of Experimental and Clinical Assisted Reproduction
SN - 1743-1050
ER -