Tissue engineering, stem cells and cloning: Current concepts and changing trends

Anthony Atala

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Organ damage or loss can occur from congenital disorders, cancer, trauma, infection, inflammation, iatrogenic injuries or other conditions and often necessitates reconstruction or replacement. Replacement may take the form of organ transplant. At present, there is a severe shortage of donor organs that is worsening with the aging of the population. Tissue engineering follows the principles of cell transplantation, materials science and engineering towards the development of biological substitutes that can restore and maintain normal tissue function. Therapeutic cloning involves the introduction of a nucleus from a donor cell into an enucleated oocyte to generate embryonic stem cell lines whose genetic material is identical to that of its source. These autologous stem cells have the potential to become almost any type of cell in the adult body, and thus would be useful in tissue and organ replacement applications. This paper reviews recent advances in stem cell research and regenerative medicine, and describes the clinical applications of these technologies as novel therapies for tissue or organ loss.

Original languageEnglish
Pages (from-to)879-892
Number of pages14
JournalExpert Opinion on Biological Therapy
Volume5
Issue number7
DOIs
StatePublished - Jul 1 2005
Externally publishedYes

Fingerprint

Cloning
Tissue Engineering
Stem cells
Tissue engineering
Organism Cloning
Stem Cells
Tissue Donors
Tissue
Stem Cell Research
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Regenerative Medicine
Cell Transplantation
Wounds and Injuries
Embryonic Stem Cells
Cell- and Tissue-Based Therapy
Transplantation (surgical)
Oocytes
Transplants
Materials science
Inflammation

Keywords

  • Regenerative medicine
  • Stem cells
  • Therapeutic cloning

ASJC Scopus subject areas

  • Pharmacology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics
  • Immunology

Cite this

Tissue engineering, stem cells and cloning : Current concepts and changing trends. / Atala, Anthony.

In: Expert Opinion on Biological Therapy, Vol. 5, No. 7, 01.07.2005, p. 879-892.

Research output: Contribution to journalArticle

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