Tissue Engineering of the Nervous System

Paul Dalton, Alan Harvey, Martin Oudega, Giles Plant

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations

Abstract

This chapter outlines the various issues and approaches associated with tissue engineering in the nervous system. The molecular and cellular environment demands particular emphasis, as does the natural anatomical structure and relevant animal models for repair. However, given the complex interactions between neurons, glia, and the immune system in vivo it is important to note that tissue engineering to date has only encompassed limited areas of neuroscience. The induction of neurite outgrowth and nerve regeneration with neurotrophic factors and the use of ECM proteins/peptides have attracted the most attention, while materials for neuroprotection strategies has so far been more limited. The chapter details that tissue engineering therapies for treating traumatic injury versus degenerative diseases differ greatly. Genetic modification of cells prior to transplantation into the injured brain and spinal cord can increase neuronal survival and enhance the regeneration response.

Original languageEnglish (US)
Title of host publicationTissue Engineering
PublisherElsevier Inc.
Pages611-647
Number of pages37
ISBN (Print)9780123708694
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Engineering(all)

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