Tissue engineering of the bladder

German Falke, Jorge Caffaratti, Anthony Atala

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

When gastrointestinal tissue is used for bladder augmentation or replacement, multiple complications may ensue, such as infection, metabolic disturbances, urolithiasis, perforation, increased mucous production, and malignancy. Therefore, alternative methods are being sought for cystoplasty. There has been a resurgence of interest in the use of acellular collagen-based matrices as scaffolds for bladder regeneration. Experimental work involving several collagen matrices, such as allogenic bladder and intestinal tissues, is currently being conducted in several academic centers. Recently, functional bladder tissue has been engineered using selective cell transplantation. The approach that has been followed for bioengineering of bladder tissue involves the use of autologous cells, thus avoiding rejection, whereby a biopsy of tissue is obtained from the host, after which the cells are dissociated and expanded in vitro, reattached to a matrix, and implanted into the same host.

Original languageEnglish
Pages (from-to)36-43
Number of pages8
JournalWorld Journal of Urology
Volume18
Issue number1
StatePublished - Dec 1 2000
Externally publishedYes

Fingerprint

Tissue Engineering
Urinary Bladder
Collagen
Bioengineering
Urolithiasis
Cell Transplantation
Regeneration
Biopsy
Infection
Neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Falke, G., Caffaratti, J., & Atala, A. (2000). Tissue engineering of the bladder. World Journal of Urology, 18(1), 36-43.

Tissue engineering of the bladder. / Falke, German; Caffaratti, Jorge; Atala, Anthony.

In: World Journal of Urology, Vol. 18, No. 1, 01.12.2000, p. 36-43.

Research output: Contribution to journalArticle

Falke, G, Caffaratti, J & Atala, A 2000, 'Tissue engineering of the bladder', World Journal of Urology, vol. 18, no. 1, pp. 36-43.
Falke G, Caffaratti J, Atala A. Tissue engineering of the bladder. World Journal of Urology. 2000 Dec 1;18(1):36-43.
Falke, German ; Caffaratti, Jorge ; Atala, Anthony. / Tissue engineering of the bladder. In: World Journal of Urology. 2000 ; Vol. 18, No. 1. pp. 36-43.
@article{c123a5ad5cb84870b2cc4ecf74dfd339,
title = "Tissue engineering of the bladder",
abstract = "When gastrointestinal tissue is used for bladder augmentation or replacement, multiple complications may ensue, such as infection, metabolic disturbances, urolithiasis, perforation, increased mucous production, and malignancy. Therefore, alternative methods are being sought for cystoplasty. There has been a resurgence of interest in the use of acellular collagen-based matrices as scaffolds for bladder regeneration. Experimental work involving several collagen matrices, such as allogenic bladder and intestinal tissues, is currently being conducted in several academic centers. Recently, functional bladder tissue has been engineered using selective cell transplantation. The approach that has been followed for bioengineering of bladder tissue involves the use of autologous cells, thus avoiding rejection, whereby a biopsy of tissue is obtained from the host, after which the cells are dissociated and expanded in vitro, reattached to a matrix, and implanted into the same host.",
author = "German Falke and Jorge Caffaratti and Anthony Atala",
year = "2000",
month = "12",
day = "1",
language = "English",
volume = "18",
pages = "36--43",
journal = "World Journal of Urology",
issn = "0724-4983",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Tissue engineering of the bladder

AU - Falke, German

AU - Caffaratti, Jorge

AU - Atala, Anthony

PY - 2000/12/1

Y1 - 2000/12/1

N2 - When gastrointestinal tissue is used for bladder augmentation or replacement, multiple complications may ensue, such as infection, metabolic disturbances, urolithiasis, perforation, increased mucous production, and malignancy. Therefore, alternative methods are being sought for cystoplasty. There has been a resurgence of interest in the use of acellular collagen-based matrices as scaffolds for bladder regeneration. Experimental work involving several collagen matrices, such as allogenic bladder and intestinal tissues, is currently being conducted in several academic centers. Recently, functional bladder tissue has been engineered using selective cell transplantation. The approach that has been followed for bioengineering of bladder tissue involves the use of autologous cells, thus avoiding rejection, whereby a biopsy of tissue is obtained from the host, after which the cells are dissociated and expanded in vitro, reattached to a matrix, and implanted into the same host.

AB - When gastrointestinal tissue is used for bladder augmentation or replacement, multiple complications may ensue, such as infection, metabolic disturbances, urolithiasis, perforation, increased mucous production, and malignancy. Therefore, alternative methods are being sought for cystoplasty. There has been a resurgence of interest in the use of acellular collagen-based matrices as scaffolds for bladder regeneration. Experimental work involving several collagen matrices, such as allogenic bladder and intestinal tissues, is currently being conducted in several academic centers. Recently, functional bladder tissue has been engineered using selective cell transplantation. The approach that has been followed for bioengineering of bladder tissue involves the use of autologous cells, thus avoiding rejection, whereby a biopsy of tissue is obtained from the host, after which the cells are dissociated and expanded in vitro, reattached to a matrix, and implanted into the same host.

UR - http://www.scopus.com/inward/record.url?scp=0034136434&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034136434&partnerID=8YFLogxK

M3 - Article

C2 - 10766042

AN - SCOPUS:0034136434

VL - 18

SP - 36

EP - 43

JO - World Journal of Urology

JF - World Journal of Urology

SN - 0724-4983

IS - 1

ER -