Tissue engineering, one of the major components of regenerative medicine, follows the principles of cell transplantation, materials science, and engineering to develop biological substitutes that can restore and maintain normal organ function. Tissue engineering strategies generally fall into two categories: the use of acellular matrices designed to direct the body's natural ability to use its own cells to regenerate damaged tissue, and the use of matrices seeded with cells in the laboratory to produce novel tissues and organs. Efforts in regenerative medicine are currently underway experimentally for virtually every type of tissue and organ in the human body. As regenerative medicine incorporates the fields of tissue engineering, cell biology, nuclear transfer, and materials science, personnel who have mastered the techniques of cell harvest, culture, expansion, and transplantation, as well as polymer design, are essential for the successful application of these technologies to extend human life. Various tissues are at different stages of development, with some already being used clinically, a few in preclinical trials and some in the discovery stage. Recent progress suggests that engineered tissues may have an expanded clinical applicability in the future and may represent a viable therapeutic option for those who would benefit from the life-extending benefits of tissue replacement or repair.
|Original language||English (US)|
|Title of host publication||Regenerative Nephrology|
|Number of pages||12|
|State||Published - Dec 1 2011|
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