Abstract
Tissue engineering combines the principles of materials and cell transplantation to develop substitute tissues and/or promote endogenous regeneration. The approach was initially conceived to address the critical gap between the growing number of patients on the waiting list for organ transplantation, but it will focus increasingly on prevalent conditions in which the restoration of functional tissue would answer a currently unmet medical need. Significant progress has been realized since its inception, but to date only a handful of complex products incorporating cells together with scaffolds have gained regulatory approval, and these have only achieved limited market penetration. Nonetheless, recent clinical reports with multiple years of patient follow-up document the maturation of the field and validate the development of neo-tissues and neo-organs, and the industry is rapidly becoming economically robust. The combination of advances in both clinical development and commercialization indicates that these technologies will reach increasing numbers of patients in the years to come.
| Original language | English |
|---|---|
| Title of host publication | Principles of Tissue Engineering: Fourth Edition |
| Publisher | Elsevier Inc. |
| Pages | 83-123 |
| Number of pages | 41 |
| ISBN (Print) | 9780123983589 |
| DOIs | |
| State | Published - Nov 1 2013 |
| Externally published | Yes |
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Keywords
- Biomaterial
- Cell-seeded scaffold
- Decellularized tissue
- Extracellular matrix
- Scaffold material
- Stem cell
- Tissue engineering
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Tissue Engineering : Future Perspectives. / Furth, Mark E.; Atala, Anthony.
Principles of Tissue Engineering: Fourth Edition. Elsevier Inc., 2013. p. 83-123.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Tissue Engineering
T2 - Future Perspectives
AU - Furth, Mark E.
AU - Atala, Anthony
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Tissue engineering combines the principles of materials and cell transplantation to develop substitute tissues and/or promote endogenous regeneration. The approach was initially conceived to address the critical gap between the growing number of patients on the waiting list for organ transplantation, but it will focus increasingly on prevalent conditions in which the restoration of functional tissue would answer a currently unmet medical need. Significant progress has been realized since its inception, but to date only a handful of complex products incorporating cells together with scaffolds have gained regulatory approval, and these have only achieved limited market penetration. Nonetheless, recent clinical reports with multiple years of patient follow-up document the maturation of the field and validate the development of neo-tissues and neo-organs, and the industry is rapidly becoming economically robust. The combination of advances in both clinical development and commercialization indicates that these technologies will reach increasing numbers of patients in the years to come.
AB - Tissue engineering combines the principles of materials and cell transplantation to develop substitute tissues and/or promote endogenous regeneration. The approach was initially conceived to address the critical gap between the growing number of patients on the waiting list for organ transplantation, but it will focus increasingly on prevalent conditions in which the restoration of functional tissue would answer a currently unmet medical need. Significant progress has been realized since its inception, but to date only a handful of complex products incorporating cells together with scaffolds have gained regulatory approval, and these have only achieved limited market penetration. Nonetheless, recent clinical reports with multiple years of patient follow-up document the maturation of the field and validate the development of neo-tissues and neo-organs, and the industry is rapidly becoming economically robust. The combination of advances in both clinical development and commercialization indicates that these technologies will reach increasing numbers of patients in the years to come.
KW - Biomaterial
KW - Cell-seeded scaffold
KW - Decellularized tissue
KW - Extracellular matrix
KW - Scaffold material
KW - Stem cell
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84903246585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903246585&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-398358-9.00006-9
DO - 10.1016/B978-0-12-398358-9.00006-9
M3 - Chapter
AN - SCOPUS:84903246585
SN - 9780123983589
SP - 83
EP - 123
BT - Principles of Tissue Engineering: Fourth Edition
PB - Elsevier Inc.
ER -