Tissue Engineering: Future Perspectives

Mark E. Furth, Anthony Atala

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations

Abstract

Tissue engineering combines the principles of materials and cell transplantation to develop substitute tissues and/or promote endogenous regeneration. The approach was initially conceived to address the critical gap between the growing number of patients on the waiting list for organ transplantation, but it will focus increasingly on prevalent conditions in which the restoration of functional tissue would answer a currently unmet medical need. Significant progress has been realized since its inception, but to date only a handful of complex products incorporating cells together with scaffolds have gained regulatory approval, and these have only achieved limited market penetration. Nonetheless, recent clinical reports with multiple years of patient follow-up document the maturation of the field and validate the development of neo-tissues and neo-organs, and the industry is rapidly becoming economically robust. The combination of advances in both clinical development and commercialization indicates that these technologies will reach increasing numbers of patients in the years to come.

Original languageEnglish (US)
Title of host publicationPrinciples of Tissue Engineering
Subtitle of host publicationFourth Edition
PublisherElsevier Inc.
Pages83-123
Number of pages41
ISBN (Print)9780123983589
DOIs
StatePublished - Nov 1 2013

Keywords

  • Biomaterial
  • Cell-seeded scaffold
  • Decellularized tissue
  • Extracellular matrix
  • Scaffold material
  • Stem cell
  • Tissue engineering

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Furth, M. E., & Atala, A. (2013). Tissue Engineering: Future Perspectives. In Principles of Tissue Engineering: Fourth Edition (pp. 83-123). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398358-9.00006-9