Tissue engineering and regenerative medicine potentialities of materials - Based novel constructs - A review

Hafiz M.N. Iqbal, Kuldeep Dhama, Ashok Munjal, Rekha Khandia, Kumaragurubaran Karthik, Maryam Dadar, Swati Sachan, Shyma K. Latheef, Sunil K. Joshi

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Background: In recent years, tissue engineering (TE) and regenerative medicine (RM) are rapidly evolving fields. TE and RM are part of the biomedical field, and both are emergent research areas with a high impact on medical issues. The development of new types of novel, effective and highly reliable engineering constructs is essential to tackle many human health-related diseases. To this end, materials science technology offers an excellent engineering exploitability. Objective: The objective of this review is to extend the current knowledge in the field of biomaterials for TE and RM including human-made novel constructs though using different materials and strategies. Methods: We extensively reviewed, analyzed and compiled salient information from the authentic published literature available in PubMed and other scientific databases. Results: The multi-shape novel constructs have been fabricated for a variety of applications in bio and non-bio sectors of the modern world. As compared to the natural bulk material, engineering of their constructs particularly at the micro and nano-level impart unique characteristics including surface area and surface functionality enhancement, improved thermo-mechanical and electrical conductivity, etc. The materials-based engineered constructs have been exploited in biotechnology at large and biomedical in particular. Conclusion: The most promising applications include their utilization as a vehicle to deliver therapeutic agents, as scaffolds for engineering various tissues and also serve as an integrated part of biomedical implants, etc. Herein, we reviewed bio-nano-technological advancements from a TE and RM perspective in particular and envision directions of future developments.

Original languageEnglish (US)
Pages (from-to)29-40
Number of pages12
JournalCurrent Regenerative Medicine
Volume6
Issue number1
DOIs
StatePublished - 2017
Externally publishedYes

Keywords

  • Biomaterials
  • Bone tissue engineering
  • Heart tissue engineering
  • Novel constructs
  • Organs
  • Regeneration
  • Skin tissue engineering
  • Tissue engineering

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology
  • Cell Biology

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