Tissue-engineered skin in the healing of wound stumps from limb amputations secondary to purpura fulminans

J. E. Greenberg, A. F. Falabella, Y. M. Bello, Lawrence A. Schachner

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Currently wound treatment options of amputation stumps due to purpura fulminans include healing by secondary intention from wound debridement, split-thickness skin grafting, tissue and muscle flaps, plantar skin free transfer, skin expansion, artificial skin, and hyperbaric oxygen therapy. We saw a 6-month-old girl with purpura fulminans as a complication of meningococcemia. She developed necrosis of the distal extremities resulting in bilateral amputation of the lower limbs. Shortly thereafter the leg stumps also became necrosed and she underwent unsuccessful split-thickness grafts of lower limb ulcers. The patient's difficult-to-heal wounds made her an excellent candidate for treatment with tissue-engineered skin. At 10 months of age, this was applied to her previously nonhealing wounds. The tissue-engineered skin induced rapid healing of the patient's chronic amputation stump ulcers and provided her with substantial pain relief. In conclusion, tissue-engineered skin appears to be a potential beneficial treatment for chronic wounds in children with nonhealing amputation stumps.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalPediatric Dermatology
Issue number2
StatePublished - Mar 1 2003

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology


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