Tissue-Engineered Organs

Steve J. Hodges, Anthony Atala

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Human organs are exposed to a variety of possible injuries from the time the fetus develops. Individuals may suffer from many conditions that may lead to organ damage or loss and necessitate eventual reconstruction or replacement. In most cases, the replacement of lost or deficient tissues with functionally equivalent autologous tissues would improve the outcome for patients immensely. Tissue-engineering therapies have been developed in order to achieve this goal. The development of functional organ systems from the building blocks of cells, scaffolding, and growth factors is a Herculean task, however, as evidenced by the few successful tissue-engineering technologies currently in clinical use. There have been successes, however, as evidenced by functioning autologous bioengineered tissues that have been implanted in humans - including trachea, blood vessels, pulmonary valves, endothelialized vascular stents, and urinary bladder. An examination of the building blocks of tissue-engineering strategies, as well the successful applications of these techniques in human clinical applications, provides an insight into the difficulties facing scientists as they seek to develop more complex bioengineered organs.

Original languageEnglish (US)
Title of host publicationPrinciples of Tissue Engineering
Subtitle of host publicationFourth Edition
PublisherElsevier Inc.
Pages1765-1777
Number of pages13
ISBN (Print)9780123983589
DOIs
StatePublished - Nov 1 2013

Keywords

  • Acellular matrix
  • Bladder
  • Cloning
  • Donor tissue
  • Growth factor
  • Implant
  • Kidney
  • Regenerative medicine
  • Scaffolding
  • Skin
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Hodges, S. J., & Atala, A. (2013). Tissue-Engineered Organs. In Principles of Tissue Engineering: Fourth Edition (pp. 1765-1777). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398358-9.00085-9