Timing of cyclin D1 expression within G1 phase is controlled by Rho

Catherine Welsh, Kristin Roovers, Jessie Villanueva, Yun Qi Liu, Martin A. Schwartz, Richard K. Assoian

Research output: Contribution to journalArticle

253 Citations (Scopus)

Abstract

The expression of cyclin D1 in mid-G1 phase is associated with sustained ERK activity, and we show here that Rho is required for the sustained ERK signal. However, we also report that Rho inhibits an alternative Rac/Cdc42-dependent pathway, which results in a strikingly early G1-phase expression of cyclin D1. Thus, cyclin D1 is induced in mid-G1 phase because a Rho switch couples its expression to sustained ERK activity rather than Rac and Cdc42. Our results show that Rho is crucial for maintaining the correct timing of cyclin D1 expression in G1 phase and describe a new role for cytoskeletal integrity in the regulation of cell cycle progression.

Original languageEnglish
Pages (from-to)950-957
Number of pages8
JournalNature Cell Biology
Volume3
Issue number11
DOIs
StatePublished - Dec 1 2001

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Cyclin D1
G1 Phase
Cell Cycle

ASJC Scopus subject areas

  • Cell Biology

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Welsh, C., Roovers, K., Villanueva, J., Liu, Y. Q., Schwartz, M. A., & Assoian, R. K. (2001). Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nature Cell Biology, 3(11), 950-957. https://doi.org/10.1038/ncb1101-950

Timing of cyclin D1 expression within G1 phase is controlled by Rho. / Welsh, Catherine; Roovers, Kristin; Villanueva, Jessie; Liu, Yun Qi; Schwartz, Martin A.; Assoian, Richard K.

In: Nature Cell Biology, Vol. 3, No. 11, 01.12.2001, p. 950-957.

Research output: Contribution to journalArticle

Welsh, C, Roovers, K, Villanueva, J, Liu, YQ, Schwartz, MA & Assoian, RK 2001, 'Timing of cyclin D1 expression within G1 phase is controlled by Rho', Nature Cell Biology, vol. 3, no. 11, pp. 950-957. https://doi.org/10.1038/ncb1101-950
Welsh C, Roovers K, Villanueva J, Liu YQ, Schwartz MA, Assoian RK. Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nature Cell Biology. 2001 Dec 1;3(11):950-957. https://doi.org/10.1038/ncb1101-950
Welsh, Catherine ; Roovers, Kristin ; Villanueva, Jessie ; Liu, Yun Qi ; Schwartz, Martin A. ; Assoian, Richard K. / Timing of cyclin D1 expression within G1 phase is controlled by Rho. In: Nature Cell Biology. 2001 ; Vol. 3, No. 11. pp. 950-957.
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