Timing of chemotherapy and surgery in a murine osteosarcoma model

R. S. Bell, Y. F. Roth, M. C. Gebhardt, A. E. Rosenberg, Andrew Rosenberg, H. D. Suit

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The sequential use of chemotherapy and surgery in the treatment of osteosarcoma developed in an empirical fashion without the benefit of investigations in animal models. The MGH-OGS murine osteosarcoma is a transplantable tumor that resembles the human disease with respect to histology, local invasiveness, metastatic characteristics, tumor ploidy, and its response to chemotherapy. We have used this tumor model to investigate the efficacy of preoperative, perioperative, and postoperative chemotherapy on the development of pulmonary metastases in three different experimental protocols. In each experimental design, perioperative chemotherapy demonstrated a significant advantage in preventing systemic relapse.

Original languageEnglish
Pages (from-to)5533-5538
Number of pages6
JournalCancer Research
Volume48
Issue number19
StatePublished - Jan 1 1988
Externally publishedYes

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Osteosarcoma
Drug Therapy
Neoplasms
Ploidies
Histology
Research Design
Animal Models
Neoplasm Metastasis
Recurrence
Lung
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bell, R. S., Roth, Y. F., Gebhardt, M. C., Rosenberg, A. E., Rosenberg, A., & Suit, H. D. (1988). Timing of chemotherapy and surgery in a murine osteosarcoma model. Cancer Research, 48(19), 5533-5538.

Timing of chemotherapy and surgery in a murine osteosarcoma model. / Bell, R. S.; Roth, Y. F.; Gebhardt, M. C.; Rosenberg, A. E.; Rosenberg, Andrew; Suit, H. D.

In: Cancer Research, Vol. 48, No. 19, 01.01.1988, p. 5533-5538.

Research output: Contribution to journalArticle

Bell, RS, Roth, YF, Gebhardt, MC, Rosenberg, AE, Rosenberg, A & Suit, HD 1988, 'Timing of chemotherapy and surgery in a murine osteosarcoma model', Cancer Research, vol. 48, no. 19, pp. 5533-5538.
Bell RS, Roth YF, Gebhardt MC, Rosenberg AE, Rosenberg A, Suit HD. Timing of chemotherapy and surgery in a murine osteosarcoma model. Cancer Research. 1988 Jan 1;48(19):5533-5538.
Bell, R. S. ; Roth, Y. F. ; Gebhardt, M. C. ; Rosenberg, A. E. ; Rosenberg, Andrew ; Suit, H. D. / Timing of chemotherapy and surgery in a murine osteosarcoma model. In: Cancer Research. 1988 ; Vol. 48, No. 19. pp. 5533-5538.
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