Abstract
Introduction: We aimed to determine the time and predictive factors of semen quality improvement in men with severe oligospermia after microsurgical varicocelectomy. Methods: Men with total motile sperm count (TMSC) <5 million on two semen analyses were identified from May 2015 to August 2017. Postoperative semen analysis was collected at 3-6 months and >6 months. We evaluated preoperative factors for successful semen quality upgrading based on assisted reproductive technology (ART) eligibility: in vitro fertilization [IVF] (<5 million), intrauterine insemination (IUI) (5-9 million), and natural pregnancy (>9 million). We compared men with TMSC <5 million to those with TMSC 5-9 million. Data are reported as means and standard error of the mean (SEM). Pregnancy data was collected by phone interview at >6 months postoperatively Results: A total of 33 men were included. TMSC improved from 1.5±0.2 to 7.3±1.8 million at 3-6 months (p<0.05) and 12.2±3.6 million at >6 months (p<0.05). There was no statistical difference in TMSC between 3-6 months and >6 months. Sixteen (48.5%) men upgraded semen quality into the range of natural pregnancy. Preoperative TMSC from 2-5 million was predictive of upgrading semen quality. Twenty-four couples were contacted by phone; 20 were attempting pregnancy in the postoperative period and five (25%) of them had achieved natural pregnancy. Conclusions: Men with TMSC <5 million can expect the largest improvement in TMSC from 3-6 months postoperatively with minimal improvement thereafter. Preoperative TMSC >2 million was most predictive of semen quality upgrading.
| Original language | English (US) |
|---|---|
| Pages (from-to) | E66-E69 |
| Journal | Canadian Urological Association Journal |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2019 |
Fingerprint
ASJC Scopus subject areas
- Urology
Cite this
Time to improvement in semen parameters after microsurgical varicocelectomy in men with severe oligospermia. / Masterson, Thomas A.; Greer, Aubrey B.; Ramasamy, Ranjith.
In: Canadian Urological Association Journal, Vol. 13, No. 3, 01.03.2019, p. E66-E69.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Time to improvement in semen parameters after microsurgical varicocelectomy in men with severe oligospermia
AU - Masterson, Thomas A.
AU - Greer, Aubrey B.
AU - Ramasamy, Ranjith
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Introduction: We aimed to determine the time and predictive factors of semen quality improvement in men with severe oligospermia after microsurgical varicocelectomy. Methods: Men with total motile sperm count (TMSC) <5 million on two semen analyses were identified from May 2015 to August 2017. Postoperative semen analysis was collected at 3-6 months and >6 months. We evaluated preoperative factors for successful semen quality upgrading based on assisted reproductive technology (ART) eligibility: in vitro fertilization [IVF] (<5 million), intrauterine insemination (IUI) (5-9 million), and natural pregnancy (>9 million). We compared men with TMSC <5 million to those with TMSC 5-9 million. Data are reported as means and standard error of the mean (SEM). Pregnancy data was collected by phone interview at >6 months postoperatively Results: A total of 33 men were included. TMSC improved from 1.5±0.2 to 7.3±1.8 million at 3-6 months (p<0.05) and 12.2±3.6 million at >6 months (p<0.05). There was no statistical difference in TMSC between 3-6 months and >6 months. Sixteen (48.5%) men upgraded semen quality into the range of natural pregnancy. Preoperative TMSC from 2-5 million was predictive of upgrading semen quality. Twenty-four couples were contacted by phone; 20 were attempting pregnancy in the postoperative period and five (25%) of them had achieved natural pregnancy. Conclusions: Men with TMSC <5 million can expect the largest improvement in TMSC from 3-6 months postoperatively with minimal improvement thereafter. Preoperative TMSC >2 million was most predictive of semen quality upgrading.
AB - Introduction: We aimed to determine the time and predictive factors of semen quality improvement in men with severe oligospermia after microsurgical varicocelectomy. Methods: Men with total motile sperm count (TMSC) <5 million on two semen analyses were identified from May 2015 to August 2017. Postoperative semen analysis was collected at 3-6 months and >6 months. We evaluated preoperative factors for successful semen quality upgrading based on assisted reproductive technology (ART) eligibility: in vitro fertilization [IVF] (<5 million), intrauterine insemination (IUI) (5-9 million), and natural pregnancy (>9 million). We compared men with TMSC <5 million to those with TMSC 5-9 million. Data are reported as means and standard error of the mean (SEM). Pregnancy data was collected by phone interview at >6 months postoperatively Results: A total of 33 men were included. TMSC improved from 1.5±0.2 to 7.3±1.8 million at 3-6 months (p<0.05) and 12.2±3.6 million at >6 months (p<0.05). There was no statistical difference in TMSC between 3-6 months and >6 months. Sixteen (48.5%) men upgraded semen quality into the range of natural pregnancy. Preoperative TMSC from 2-5 million was predictive of upgrading semen quality. Twenty-four couples were contacted by phone; 20 were attempting pregnancy in the postoperative period and five (25%) of them had achieved natural pregnancy. Conclusions: Men with TMSC <5 million can expect the largest improvement in TMSC from 3-6 months postoperatively with minimal improvement thereafter. Preoperative TMSC >2 million was most predictive of semen quality upgrading.
UR - http://www.scopus.com/inward/record.url?scp=85063370521&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063370521&partnerID=8YFLogxK
U2 - 10.5489/cuaj.5408
DO - 10.5489/cuaj.5408
M3 - Article
AN - SCOPUS:85063370521
VL - 13
SP - E66-E69
JO - Canadian Urological Association Journal
JF - Canadian Urological Association Journal
SN - 1920-1214
IS - 3
ER -