Time-specific contribution of the supplementary motor area to intermanual transfer of procedural knowledge

Monica Perez, Satoshi Tanaka, Steven P. Wise, Daniel T. Willingham, Leonardo G. Cohen

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The supplementary motor area (SMA) makes a crucial contribution to intermanual transfer: the ability to use one hand to perform a skill practiced and learned with the other hand. However, the timing of this contribution relative to movement remains unknown. Here, 33 healthy volunteers performed a 12 item sequence in the serial reaction time task. During training, each participant responded to a sequence of visual cues presented at 1 Hz by pressing one of four keys with their right hand. The measure of intermanual transfer was response time (RT) during repetition of the trained sequence with the left hand, which was at rest during learning. Participants were divided into three groups, which did not differ in their learning rates or amounts. In two groups, 1 Hz repetitive transcranial magnetic stimulation induced transient virtual lesions of the SMA during training, either 100 ms before each cue (the premovement group) or during each key press (the movement group). The third group received sham stimulation (the sham group). After training with the right hand, RTs for performance with the left (transfer) hand were longer for the premovement group than for the movement or sham groups. Thus, the most crucial contribution of SMA to intermanual transfer occurs in the interval between movements, when the memory of a previous movement plays a role in encoding specific sequences. These results provide insight into frontal lobe contributions to procedural knowledge.

Original languageEnglish (US)
Pages (from-to)9664-9669
Number of pages6
JournalJournal of Neuroscience
Volume28
Issue number39
DOIs
StatePublished - Sep 24 2008
Externally publishedYes

Fingerprint

Motor Cortex
Hand
Reaction Time
Cues
Learning
Aptitude
Transcranial Magnetic Stimulation
Frontal Lobe
Transfer (Psychology)
Healthy Volunteers

Keywords

  • Learning and memory
  • Motor control
  • Motor cortex
  • Motor learning
  • Plasticity
  • Training

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Time-specific contribution of the supplementary motor area to intermanual transfer of procedural knowledge. / Perez, Monica; Tanaka, Satoshi; Wise, Steven P.; Willingham, Daniel T.; Cohen, Leonardo G.

In: Journal of Neuroscience, Vol. 28, No. 39, 24.09.2008, p. 9664-9669.

Research output: Contribution to journalArticle

Perez, Monica ; Tanaka, Satoshi ; Wise, Steven P. ; Willingham, Daniel T. ; Cohen, Leonardo G. / Time-specific contribution of the supplementary motor area to intermanual transfer of procedural knowledge. In: Journal of Neuroscience. 2008 ; Vol. 28, No. 39. pp. 9664-9669.
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