Time-dependent variations of the skin barrier function in humans: Transepidermal water loss, stratum corneum hydration, skin surface pH, and skin temperature

Gil Yosipovitch, G. L. Xiong, E. Haus, L. Sackett-Lundeen, I. Ashkenazi, H. I. Maibach

Research output: Chapter in Book/Report/Conference proceedingChapter

191 Citations (Scopus)

Abstract

Although circadian rhythms have been described for many human functions, there are minimal data on circadian rhythms related to skin physiology. This study investigated the circadian rhythmicity of skin variables related to skin barrier function in humans. We measured transepidermal water loss, stratum corneum moisture, skin surface pH, and skin temperature in 16 healthy volunteers (nine men and seven women, aged 23-53 y). Subjects were sampled every 2 h in two sessions over a 24 h span. Twelve samples were obtained for each variable in the following sites: forehead, forearm, upper back, and shin. We used cosinor analysis and ANOVA to validate observed differences. Time-dependent rhythms were detected in most skin variables except in stratum corneum hydration. We found a statistically significant circadian rhythmicity characterized by cosinor analysis in transepidermal water loss, skin surface pH, and skin temperature on the forearm, forehead, and shin. Peak-trough differences occurred in all locations. The values of the same variables measured at different sites correlated positively, whereas the values of the different variables did not. These results suggest that skin permeability is higher in the evening and night than in the morning. These data may be clinically relevant in several aspects applied to skin physiology and topical drug application.

Original languageEnglish (US)
Title of host publicationJournal of Investigative Dermatology
PublisherNature Publishing Group
Pages20-23
Number of pages4
Volume110
Edition1
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Fingerprint

Skin Temperature
Hydration
Cornea
Skin
Water
Skin Physiological Phenomena
Forehead
Periodicity
Circadian Rhythm
Forearm
Temperature
Physiology
Permeability
Analysis of Variance
Healthy Volunteers
Analysis of variance (ANOVA)
Moisture
Pharmaceutical Preparations

Keywords

  • Circadian rhythms
  • Cosinor analysis
  • Skin physiology

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Yosipovitch, G., Xiong, G. L., Haus, E., Sackett-Lundeen, L., Ashkenazi, I., & Maibach, H. I. (1998). Time-dependent variations of the skin barrier function in humans: Transepidermal water loss, stratum corneum hydration, skin surface pH, and skin temperature. In Journal of Investigative Dermatology (1 ed., Vol. 110, pp. 20-23). Nature Publishing Group. https://doi.org/10.1046/j.1523-1747.1998.00069.x

Time-dependent variations of the skin barrier function in humans : Transepidermal water loss, stratum corneum hydration, skin surface pH, and skin temperature. / Yosipovitch, Gil; Xiong, G. L.; Haus, E.; Sackett-Lundeen, L.; Ashkenazi, I.; Maibach, H. I.

Journal of Investigative Dermatology. Vol. 110 1. ed. Nature Publishing Group, 1998. p. 20-23.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yosipovitch, G, Xiong, GL, Haus, E, Sackett-Lundeen, L, Ashkenazi, I & Maibach, HI 1998, Time-dependent variations of the skin barrier function in humans: Transepidermal water loss, stratum corneum hydration, skin surface pH, and skin temperature. in Journal of Investigative Dermatology. 1 edn, vol. 110, Nature Publishing Group, pp. 20-23. https://doi.org/10.1046/j.1523-1747.1998.00069.x
Yosipovitch G, Xiong GL, Haus E, Sackett-Lundeen L, Ashkenazi I, Maibach HI. Time-dependent variations of the skin barrier function in humans: Transepidermal water loss, stratum corneum hydration, skin surface pH, and skin temperature. In Journal of Investigative Dermatology. 1 ed. Vol. 110. Nature Publishing Group. 1998. p. 20-23 https://doi.org/10.1046/j.1523-1747.1998.00069.x
Yosipovitch, Gil ; Xiong, G. L. ; Haus, E. ; Sackett-Lundeen, L. ; Ashkenazi, I. ; Maibach, H. I. / Time-dependent variations of the skin barrier function in humans : Transepidermal water loss, stratum corneum hydration, skin surface pH, and skin temperature. Journal of Investigative Dermatology. Vol. 110 1. ed. Nature Publishing Group, 1998. pp. 20-23
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