Tight linkage of apolipoprotein C2 to myotonic dystrophy on chromosome 19

M. A. Pericak-Vance, L. H. Yamaoka, R. Assinder, W. Y. Hung, R. J. Bartlett, J. M. Stajich, P. C. Gaskell, D. A. Ross, S. Sherman, G. H. Fey, S. Humphries, R. Williamson, A. D. Roses

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The cDNA and genomic probes for apolipoprotein C2 detect two restriction fragment length polymorphisms on chromosome 19. The combined estimated percentage of heterozygosity, assuming equilibrium, is approximately 75%, ie, apolipoprotein C2 is informative in 75% of matings. We have analyzed over 350 individuals in large multigenerational families for linkage of apolipoprotein C2 to myotonic muscular dystrophy. The maximum lod score was 16.29 with the maximum recombination fraction (θ) of 0.02, with 95% confidence limits for θ of 0.001 to 0.065. Thus, apolipoprotein C2 is useful in carrier detection and prenatal diagnosis with an accuracy of about 98%.

Original languageEnglish (US)
Pages (from-to)1418-1423
Number of pages6
JournalNeurology
Volume36
Issue number11
DOIs
StatePublished - Nov 1986
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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