Thyrotrophin and prolactin response to β-(pyrazolyl-1)-alanine-2-TRH in normal males

J. A. Garcia-Centenera, J. M. Vilchez-Lafuente, F. Hervas, J. P. Alba, V. Pozuelo, D. H. Coy, Andrew V Schally

Research output: Contribution to journalArticle

Abstract

Synthetic β-(pyrazolyl-1)-alanine-2-TRH, an analog of thyrotropin releasing hormone (TRH) was administered intavenously n doses of 50, 100 and 200 μg to four normal men in order to establish the range of responses of TSH and prolactin. Ever subject showed a clear elevation in TSH and prolactin levels with all three doses. These results were compared with the incements in TSH and prolactin after the administration of the same doses of synthetic TRH. The computations of potency for bsolute levels and/or increments in TSH and prolactin at 20 and 40 min showed that the analog was at least twice as activ as TRH in releasing TSH and prolactin.

Original languageEnglish
Pages (from-to)107-109
Number of pages3
JournalHormone and Metabolic Research
Volume13
Issue number2
StatePublished - May 25 1981
Externally publishedYes

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Thyrotropin-Releasing Hormone
Thyrotropin
Alanine
Prolactin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Garcia-Centenera, J. A., Vilchez-Lafuente, J. M., Hervas, F., Alba, J. P., Pozuelo, V., Coy, D. H., & Schally, A. V. (1981). Thyrotrophin and prolactin response to β-(pyrazolyl-1)-alanine-2-TRH in normal males. Hormone and Metabolic Research, 13(2), 107-109.

Thyrotrophin and prolactin response to β-(pyrazolyl-1)-alanine-2-TRH in normal males. / Garcia-Centenera, J. A.; Vilchez-Lafuente, J. M.; Hervas, F.; Alba, J. P.; Pozuelo, V.; Coy, D. H.; Schally, Andrew V.

In: Hormone and Metabolic Research, Vol. 13, No. 2, 25.05.1981, p. 107-109.

Research output: Contribution to journalArticle

Garcia-Centenera, JA, Vilchez-Lafuente, JM, Hervas, F, Alba, JP, Pozuelo, V, Coy, DH & Schally, AV 1981, 'Thyrotrophin and prolactin response to β-(pyrazolyl-1)-alanine-2-TRH in normal males', Hormone and Metabolic Research, vol. 13, no. 2, pp. 107-109.
Garcia-Centenera JA, Vilchez-Lafuente JM, Hervas F, Alba JP, Pozuelo V, Coy DH et al. Thyrotrophin and prolactin response to β-(pyrazolyl-1)-alanine-2-TRH in normal males. Hormone and Metabolic Research. 1981 May 25;13(2):107-109.
Garcia-Centenera, J. A. ; Vilchez-Lafuente, J. M. ; Hervas, F. ; Alba, J. P. ; Pozuelo, V. ; Coy, D. H. ; Schally, Andrew V. / Thyrotrophin and prolactin response to β-(pyrazolyl-1)-alanine-2-TRH in normal males. In: Hormone and Metabolic Research. 1981 ; Vol. 13, No. 2. pp. 107-109.
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