Synthetic β-(pyrazolyl-1)-alanine-2-TRH, an analog of thyrotropin releasing hormone (TRH) was administered intavenously n doses of 50, 100 and 200 μg to four normal men in order to establish the range of responses of TSH and prolactin. Ever subject showed a clear elevation in TSH and prolactin levels with all three doses. These results were compared with the incements in TSH and prolactin after the administration of the same doses of synthetic TRH. The computations of potency for bsolute levels and/or increments in TSH and prolactin at 20 and 40 min showed that the analog was at least twice as activ as TRH in releasing TSH and prolactin.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Clinical Biochemistry
- Biochemistry, medical