Thyrotrophin and prolactin response to β-(pyrazolyl-1)-alanine-2-TRH in normal males

J. A. Garcia-Centenera, J. M. Vilchez-Lafuente, F. Hervas, J. P. Alba, V. Pozuelo, D. H. Coy, A. V. Schally

Research output: Contribution to journalArticle

Abstract

Synthetic β-(pyrazolyl-1)-alanine-2-TRH, an analog of thyrotropin releasing hormone (TRH) was administered intavenously n doses of 50, 100 and 200 μg to four normal men in order to establish the range of responses of TSH and prolactin. Ever subject showed a clear elevation in TSH and prolactin levels with all three doses. These results were compared with the incements in TSH and prolactin after the administration of the same doses of synthetic TRH. The computations of potency for bsolute levels and/or increments in TSH and prolactin at 20 and 40 min showed that the analog was at least twice as activ as TRH in releasing TSH and prolactin.

Original languageEnglish (US)
Pages (from-to)107-109
Number of pages3
JournalUnknown Journal
Volume13
Issue number2
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    Garcia-Centenera, J. A., Vilchez-Lafuente, J. M., Hervas, F., Alba, J. P., Pozuelo, V., Coy, D. H., & Schally, A. V. (1981). Thyrotrophin and prolactin response to β-(pyrazolyl-1)-alanine-2-TRH in normal males. Unknown Journal, 13(2), 107-109. https://doi.org/10.1055/s-2007-1019186