Thyroid stimulating and pigmentary effects of synthetic peptides related to α-MSH and ACTH

Andrew V Schally, A. J. Kastin, T. W. Redding, C. Y. Bowers, H. Yajima, K. Kubo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Seven synthetic peptides related to α-MSH and ACTH and eleven stereoisomeric fragments of α-MSH (sequence 6-10) were tested for their thyroid stimulating effects. This TSH-like activity was determined by following 131I release in mice injected with 131I and treated with thyroxine. N-α-acetyl-β-corticotropin-(1-24)-tetracosapeptide and β-corticotropin-(1-24)-tetracosapeptide hydrazide had the highest MSH activity and elicited the greatest effects on the blood levels of 131I. The α-MSH-(7-13)-heptapeptide which had a moderate MSH activity, also caused a significant stimulation of 131I release in mice. On the other hand, β-corticotropin-(11-24)-tetradecapeptide, which had virtually no MSH activity, possessed some TSH-like activity. D-His-D-Phe-D-Arg-D-Trp-Gly and the analogous L-pentapeptide, which were essentially free of MSH activity, had no effect on the thyroid at doses up to 100 μg. per mouse. Seven MSH-ACTH stereoisomers, which individually assayed up to 1,200 MSH U/mg., similarly had no effect on the thyroid, but L-His-D-Phe-L-Arg-L-Trp-Gly and three stereoisomers which had a low but definite MSH activity, did exert some TSH-like effects. These studies reveal that, although some relationship between MSH and TSH-like activity can be observed among peptides of the MSH-ACTH group, there is no definite correlation between these activities.

Original languageEnglish
Pages (from-to)824-829
Number of pages6
JournalMetabolism
Volume16
Issue number9
StatePublished - Sep 1 1967
Externally publishedYes

Fingerprint

Melanocyte-Stimulating Hormones
Adrenocorticotropic Hormone
Thyroid Gland
Peptides
tryptophylglycine
Cosyntropin
Stereoisomerism
Thyroxine

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Schally, A. V., Kastin, A. J., Redding, T. W., Bowers, C. Y., Yajima, H., & Kubo, K. (1967). Thyroid stimulating and pigmentary effects of synthetic peptides related to α-MSH and ACTH. Metabolism, 16(9), 824-829.

Thyroid stimulating and pigmentary effects of synthetic peptides related to α-MSH and ACTH. / Schally, Andrew V; Kastin, A. J.; Redding, T. W.; Bowers, C. Y.; Yajima, H.; Kubo, K.

In: Metabolism, Vol. 16, No. 9, 01.09.1967, p. 824-829.

Research output: Contribution to journalArticle

Schally, AV, Kastin, AJ, Redding, TW, Bowers, CY, Yajima, H & Kubo, K 1967, 'Thyroid stimulating and pigmentary effects of synthetic peptides related to α-MSH and ACTH', Metabolism, vol. 16, no. 9, pp. 824-829.
Schally AV, Kastin AJ, Redding TW, Bowers CY, Yajima H, Kubo K. Thyroid stimulating and pigmentary effects of synthetic peptides related to α-MSH and ACTH. Metabolism. 1967 Sep 1;16(9):824-829.
Schally, Andrew V ; Kastin, A. J. ; Redding, T. W. ; Bowers, C. Y. ; Yajima, H. ; Kubo, K. / Thyroid stimulating and pigmentary effects of synthetic peptides related to α-MSH and ACTH. In: Metabolism. 1967 ; Vol. 16, No. 9. pp. 824-829.
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