Thyroid hormone signaling in energy homeostasis and energy metabolism

Elizabeth A. Mcaninch, Antonio C. Bianco

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The thyroid hormone (TH) plays a significant role in diverse processes related to growth, development, differentiation, and metabolism. TH signaling modulates energy expenditure through both central and peripheral pathways. At the cellular level, the TH exerts its effects after concerted mechanisms facilitate binding to the TH receptor. In the hypothalamus, signals from a range of metabolic pathways, including appetite, temperature, afferent stimuli via the autonomic nervous system, availability of energy substrates, hormones, and other biologically active molecules, converge to maintain plasma TH at the appropriate level to preserve energy homeostasis. At the tissue level, TH actions on metabolism are controlled by transmembrane transporters, deiodinases, and TH receptors. In the modern environment, humans are susceptible to an energy surplus, which has resulted in an obesity epidemic and, thus, understanding the contribution of the TH to cellular and organism metabolism is increasingly relevant.

Original languageEnglish
Pages (from-to)77-87
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume1311
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

Thyroid Hormones
Energy Metabolism
Homeostasis
Metabolism
Thyroid Hormone Receptors
Iodide Peroxidase
Autonomic Nervous System
Neurology
Appetite
Metabolic Networks and Pathways
Growth and Development
Hypothalamus
Energy
Hormones
Obesity
Availability
Tissue
Plasmas
Molecules
Temperature

Keywords

  • Basal metabolic rate
  • Cellular metabolism
  • Deiodinases
  • Energy homeostasis
  • Thyroid hormone

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Thyroid hormone signaling in energy homeostasis and energy metabolism. / Mcaninch, Elizabeth A.; Bianco, Antonio C.

In: Annals of the New York Academy of Sciences, Vol. 1311, No. 1, 01.01.2014, p. 77-87.

Research output: Contribution to journalArticle

Mcaninch, Elizabeth A. ; Bianco, Antonio C. / Thyroid hormone signaling in energy homeostasis and energy metabolism. In: Annals of the New York Academy of Sciences. 2014 ; Vol. 1311, No. 1. pp. 77-87.
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