Thyroid hormone resistance

Roy E. Weiss, Samuel Refetoff

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Generalized resistance to thyroid hormone (GRTH) encompasses a heterogeneous group of conditions characterized by reduced responses of target tissues to thyroid hormone due to defects at the site of hormone action. In the majority of patients, GRTH is inherited as a dominant trait associated with mutations in the hormone-binding domain of the thyroid hormone receptor. GRTH serves as a prototype of other resistance syndromes for hormones that act via nuclear receptors.

Original languageEnglish (US)
Pages (from-to)363-375
Number of pages13
JournalAnnual review of medicine
Volume43
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Keywords

  • c-erb-A
  • gene
  • hyperactivity
  • mutation
  • pituitary
  • receptor
  • thyrotropin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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