Thyroid hormone resistance

Roy E Weiss, Samuel Refetoff

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Generalized resistance to thyroid hormone (GRTH) encompasses a heterogeneous group of conditions characterized by reduced responses of target tissues to thyroid hormone due to defects at the site of hormone action. In the majority of patients, GRTH is inherited as a dominant trait associated with mutations in the hormone-binding domain of the thyroid hormone receptor. GRTH serves as a prototype of other resistance syndromes for hormones that act via nuclear receptors.

Original languageEnglish (US)
Pages (from-to)363-375
Number of pages13
JournalAnnual Review of Medicine
Volume43
StatePublished - 1992
Externally publishedYes

Fingerprint

Thyroid Hormone Resistance Syndrome
Thyroid Hormones
Hormones
Thyroid Hormone Receptors
Cytoplasmic and Nuclear Receptors
Mutation
Tissue
Defects

Keywords

  • c-erb-A
  • gene
  • hyperactivity
  • mutation
  • pituitary
  • receptor
  • thyrotropin

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)

Cite this

Weiss, R. E., & Refetoff, S. (1992). Thyroid hormone resistance. Annual Review of Medicine, 43, 363-375.

Thyroid hormone resistance. / Weiss, Roy E; Refetoff, Samuel.

In: Annual Review of Medicine, Vol. 43, 1992, p. 363-375.

Research output: Contribution to journalArticle

Weiss, RE & Refetoff, S 1992, 'Thyroid hormone resistance', Annual Review of Medicine, vol. 43, pp. 363-375.
Weiss, Roy E ; Refetoff, Samuel. / Thyroid hormone resistance. In: Annual Review of Medicine. 1992 ; Vol. 43. pp. 363-375.
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