Abstract
The surfactant system and antioxidant enzyme system of the lung have chronologically similar developmental patterns, and the maturation of both systems is accelerated by glucocorticoid hormones. To investigate whether thyroid hormone might also stimulate the development of the antioxidant enzyme system as well as the surfactant system, we injected pregnant rats with triiodothyronine (T3) or diluent. Fetal T3 offspring demonstrated significantly elevated T3 levels, had significantly increased lung tissue disaturated phosphatidylcholine (DSPC) and total phospholipid content, yet had significantly decreased activities of three lung antioxidant enzymes (AOE) (superoxide dismutase, catalase, and glutathione peroxidase). When dexamethasone was administered in combination with T3, fetuses demonstrated increases in lung DSPC content but decreases in AOE of magnitude equivalent to or greater than that seen with T3 alone. These findings indicate that thyroid hormone affects surfactant and AOE development in opposite ways and may have potentially harmful as well as beneficial effects on different aspects of lung development.
| Original language | English |
|---|---|
| Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
| Volume | 253 |
| Issue number | 4 |
| State | Published - Dec 1 1987 |
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ASJC Scopus subject areas
- Physiology
Cite this
Thyroid hormone depresses antioxidant enzyme maturation in fetal rat lung. / Sosenko, Ilene; Frank, L.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 253, No. 4, 01.12.1987.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Thyroid hormone depresses antioxidant enzyme maturation in fetal rat lung
AU - Sosenko, Ilene
AU - Frank, L.
PY - 1987/12/1
Y1 - 1987/12/1
N2 - The surfactant system and antioxidant enzyme system of the lung have chronologically similar developmental patterns, and the maturation of both systems is accelerated by glucocorticoid hormones. To investigate whether thyroid hormone might also stimulate the development of the antioxidant enzyme system as well as the surfactant system, we injected pregnant rats with triiodothyronine (T3) or diluent. Fetal T3 offspring demonstrated significantly elevated T3 levels, had significantly increased lung tissue disaturated phosphatidylcholine (DSPC) and total phospholipid content, yet had significantly decreased activities of three lung antioxidant enzymes (AOE) (superoxide dismutase, catalase, and glutathione peroxidase). When dexamethasone was administered in combination with T3, fetuses demonstrated increases in lung DSPC content but decreases in AOE of magnitude equivalent to or greater than that seen with T3 alone. These findings indicate that thyroid hormone affects surfactant and AOE development in opposite ways and may have potentially harmful as well as beneficial effects on different aspects of lung development.
AB - The surfactant system and antioxidant enzyme system of the lung have chronologically similar developmental patterns, and the maturation of both systems is accelerated by glucocorticoid hormones. To investigate whether thyroid hormone might also stimulate the development of the antioxidant enzyme system as well as the surfactant system, we injected pregnant rats with triiodothyronine (T3) or diluent. Fetal T3 offspring demonstrated significantly elevated T3 levels, had significantly increased lung tissue disaturated phosphatidylcholine (DSPC) and total phospholipid content, yet had significantly decreased activities of three lung antioxidant enzymes (AOE) (superoxide dismutase, catalase, and glutathione peroxidase). When dexamethasone was administered in combination with T3, fetuses demonstrated increases in lung DSPC content but decreases in AOE of magnitude equivalent to or greater than that seen with T3 alone. These findings indicate that thyroid hormone affects surfactant and AOE development in opposite ways and may have potentially harmful as well as beneficial effects on different aspects of lung development.
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M3 - Article
C2 - 3661754
AN - SCOPUS:0023632283
VL - 253
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
SN - 0363-6143
IS - 4
ER -