Thyroid hormone depresses antioxidant enzyme maturation in fetal rat lung

Ilene Sosenko, L. Frank

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The surfactant system and antioxidant enzyme system of the lung have chronologically similar developmental patterns, and the maturation of both systems is accelerated by glucocorticoid hormones. To investigate whether thyroid hormone might also stimulate the development of the antioxidant enzyme system as well as the surfactant system, we injected pregnant rats with triiodothyronine (T3) or diluent. Fetal T3 offspring demonstrated significantly elevated T3 levels, had significantly increased lung tissue disaturated phosphatidylcholine (DSPC) and total phospholipid content, yet had significantly decreased activities of three lung antioxidant enzymes (AOE) (superoxide dismutase, catalase, and glutathione peroxidase). When dexamethasone was administered in combination with T3, fetuses demonstrated increases in lung DSPC content but decreases in AOE of magnitude equivalent to or greater than that seen with T3 alone. These findings indicate that thyroid hormone affects surfactant and AOE development in opposite ways and may have potentially harmful as well as beneficial effects on different aspects of lung development.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume253
Issue number4
StatePublished - Dec 1 1987

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Thyroid Hormones
Antioxidants
Lung
Surface-Active Agents
Enzymes
Triiodothyronine
Glutathione Peroxidase
Catalase
Dexamethasone
Glucocorticoids
Superoxide Dismutase
Phospholipids
Fetus
Hormones
disaturated lecithin

ASJC Scopus subject areas

  • Physiology

Cite this

Thyroid hormone depresses antioxidant enzyme maturation in fetal rat lung. / Sosenko, Ilene; Frank, L.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 253, No. 4, 01.12.1987.

Research output: Contribution to journalArticle

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