Thyroid hormone and the neuroglia: Both source and target

Petra Mohácsik, Anikó Zeöld, Antonio C. Bianco, Balazs Gereben

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Thyroid hormone plays a crucial role in the development and function of the nervous system. In order to bind to its nuclear receptor and regulate gene transcription thyroxine needs to be activated in the brain. This activation occurs via conversion of thyroxine to T3, which is catalyzed by the type 2 iodothyronine deiodinase (D2) in glial cells, in astrocytes, and tanycytes in the mediobasal hypothalamus. We discuss how thyroid hormone affects glial cell function followed by an overview on the finetuned regulation of T3 generation by D2 in different glial subtypes. Recent evidence on the direct paracrine impact of glial D2 on neuronal gene expression underlines the importance of glial-neuronal interaction in thyroid hormone regulation as a major regulatory pathway in the brain in health and disease.

Original languageEnglish (US)
Article number215718
JournalJournal of Thyroid Research
Volume2011
DOIs
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Thyroid hormone and the neuroglia: Both source and target'. Together they form a unique fingerprint.

  • Cite this

    Mohácsik, P., Zeöld, A., Bianco, A. C., & Gereben, B. (2011). Thyroid hormone and the neuroglia: Both source and target. Journal of Thyroid Research, 2011, [215718]. https://doi.org/10.4061/2011/215718