Thyroid hormone and cardiac function in mice deficient in thyroid hormone receptor-α or -β

An echocardiograph study

Roy E Weiss, Claudia Korcarz, Olivier Chassande, Kevin Cua, Peter M. Sadow, Eugene Koo, Jacques Samarut, Roberto Lang

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We investigated the effect of thyroid hormone (TH) receptor (TR)α and -β isoforms in TH action in the heart. Noninvasive echocardiographic measurements were made in mice homozygous for disruption of TRα (TRαO/O) or TRβ (TRβ-/-). Mice were studied at baseline, 4 wk after TH deprivation (using a low-iodine diet containing propylthiouracil), and after 4-wk treatment with TH. Baseline heart rates (HR) were similar in wild-type (WT) and TRαO/O mice but were greater in TRβ-/- mice. With TH deprivation, HR decreased 49% in WT and 37% in TRβ-/- mice and decreased only 5% in TRαO/O mice from baseline, whereas HR increased in all genotypes with TH treatment. Cardiac output (CO) and cardiac index (CI) in WT mice decreased (-31 and -32%, respectively) with TH deprivation and increased (+69 and +35%, respectively) with TH treatment. The effects of CO and CI were blunted with TH withdrawal in both TRαO/O (+8 and -2%, respectively) and TRβ-/- mice (-17 and -18%, respectively). Treatment with TH resulted in a 64% increase in LV mass in WT and a 44% increase in TRαO/O mice but only a 6% increase in TRβ-/- mice (ANOVA P < 0.05). Taken together, these data suggest that TRα and TRβ play different roles in the physiology of TH action on the heart.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume283
Issue number3 46-3
StatePublished - Sep 1 2002
Externally publishedYes

Fingerprint

Thyroid Hormone Receptors
Thyroid Hormones
Heart Rate
Cardiac Output
Propylthiouracil
Physiology
Nutrition
Analysis of variance (ANOVA)
Iodine
Analysis of Variance
Protein Isoforms
Genotype
Diet

Keywords

  • Cardiac index
  • Cardiac output
  • Left ventricular mass
  • Shortening fraction
  • Thyrotropin

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry

Cite this

Thyroid hormone and cardiac function in mice deficient in thyroid hormone receptor-α or -β : An echocardiograph study. / Weiss, Roy E; Korcarz, Claudia; Chassande, Olivier; Cua, Kevin; Sadow, Peter M.; Koo, Eugene; Samarut, Jacques; Lang, Roberto.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 283, No. 3 46-3, 01.09.2002.

Research output: Contribution to journalArticle

Weiss, Roy E ; Korcarz, Claudia ; Chassande, Olivier ; Cua, Kevin ; Sadow, Peter M. ; Koo, Eugene ; Samarut, Jacques ; Lang, Roberto. / Thyroid hormone and cardiac function in mice deficient in thyroid hormone receptor-α or -β : An echocardiograph study. In: American Journal of Physiology - Endocrinology and Metabolism. 2002 ; Vol. 283, No. 3 46-3.
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