TY - JOUR
T1 - Thyroid hormone and adrenergic signaling in the heart.
AU - Kim, Brian
AU - Carvalho-Bianco, Suzy D.
AU - Larsen, P. Reed
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2004/2
Y1 - 2004/2
N2 - Thyroid hormone action has profound consequences for the heart, ranging from atrial fibrillation to hemodynamic collapse. It has long been known that the cardiovascular signs and symptoms seen in thyrotoxicosis resemble those seen in states of catecholamine excess. However, measured concentrations of serum catecholamines in patients with thyrotoxicosis are typically normal or even low, suggesting an increase in the adrenergic responsiveness of the thyrotoxic heart. In spite of several decades of work, the question of whether thyroid hormone increases cardiac adrenergic responsiveness is still controversial. In this brief review, we consider the reasons underlying this controversy, focusing on the complexity of the adrenergic signaling cascade.
AB - Thyroid hormone action has profound consequences for the heart, ranging from atrial fibrillation to hemodynamic collapse. It has long been known that the cardiovascular signs and symptoms seen in thyrotoxicosis resemble those seen in states of catecholamine excess. However, measured concentrations of serum catecholamines in patients with thyrotoxicosis are typically normal or even low, suggesting an increase in the adrenergic responsiveness of the thyrotoxic heart. In spite of several decades of work, the question of whether thyroid hormone increases cardiac adrenergic responsiveness is still controversial. In this brief review, we consider the reasons underlying this controversy, focusing on the complexity of the adrenergic signaling cascade.
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U2 - 10.1590/S0004-27302004000100019
DO - 10.1590/S0004-27302004000100019
M3 - Review article
C2 - 15611830
AN - SCOPUS:22044449180
VL - 48
SP - 171
EP - 175
JO - Archives of endocrinology and metabolism
JF - Archives of endocrinology and metabolism
SN - 2359-3997
IS - 1
ER -