Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats - A time course study

Emerson L. Olivares, Michelle P. Marassi, Rodrigo S. Fortunato, Alba C M Da Silva, Ricardo H. Costa-E-Sousa, Iracema G. Araújo, Elisabete C. Mattos, Masako O. Masuda, Michelle A. Mulcahey, Stephen A. Huang, Antonio C. Bianco, Denise P. Carvalho

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Abstract

In humans, there is a significant decrease in serum T3 and increase in rT3 at different time points after myocardial infarction, whereas serum TSH and T4 remain unaltered. We report here a time course study of pituitary-thyroid function and thyroid hormone metabolism in rats subjected to myocardial infarction by left coronary ligation (INF). INF- and sham-operated animals were followed by serial deiodination assays and thyroid function tests, just before, and 1, 4, 8, and 12 wk after surgery. At 4 and 12 wk after INF, liver type 1 deiodinase activity was significantly lower, confirming tissue hypothyroidism. Type 3 deiodinase (D3) activity was robustly induced 1 wk after INF only in the infarcted myocardium. Reminiscent of the consumptive hypothyroidism observed in patients with large D3-expressing tumors, this induction of cardiac D3 activity was associated with a decrease in both serum T4 (∼50% decrease) and T3 (37% decrease), despite compensatory stimulation of the thyroid. Thyroid stimulation was documented by both hyperthyrotropinemia and radioiodine uptake. Serum TSH increased by 4.3-fold in the first and 3.1-fold in the fourth weeks (P < 0.01), returning to the basal levels thereafter. Thyroid sodium/iodide-symporter function increased 1 wk after INF, accompanying the increased serum TSH. We conclude that the acute decrease in serum T4 and T3 after INF is due to increased thyroid hormone catabolism from ectopic D3 expression in the heart.

Original languageEnglish
Pages (from-to)4786-4792
Number of pages7
JournalEndocrinology
Volume148
Issue number10
DOIs
StatePublished - Oct 1 2007

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Iodide Peroxidase
Thyroid Gland
Myocardial Infarction
Serum
Hypothyroidism
Thyroid Hormones
Thyroid Function Tests
Heart Neoplasms
Ligation
3-monoiodothyronine
Myocardium
Liver

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Olivares, E. L., Marassi, M. P., Fortunato, R. S., Da Silva, A. C. M., Costa-E-Sousa, R. H., Araújo, I. G., ... Carvalho, D. P. (2007). Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats - A time course study. Endocrinology, 148(10), 4786-4792. https://doi.org/10.1210/en.2007-0043

Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats - A time course study. / Olivares, Emerson L.; Marassi, Michelle P.; Fortunato, Rodrigo S.; Da Silva, Alba C M; Costa-E-Sousa, Ricardo H.; Araújo, Iracema G.; Mattos, Elisabete C.; Masuda, Masako O.; Mulcahey, Michelle A.; Huang, Stephen A.; Bianco, Antonio C.; Carvalho, Denise P.

In: Endocrinology, Vol. 148, No. 10, 01.10.2007, p. 4786-4792.

Research output: Contribution to journalArticle

Olivares, EL, Marassi, MP, Fortunato, RS, Da Silva, ACM, Costa-E-Sousa, RH, Araújo, IG, Mattos, EC, Masuda, MO, Mulcahey, MA, Huang, SA, Bianco, AC & Carvalho, DP 2007, 'Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats - A time course study', Endocrinology, vol. 148, no. 10, pp. 4786-4792. https://doi.org/10.1210/en.2007-0043
Olivares EL, Marassi MP, Fortunato RS, Da Silva ACM, Costa-E-Sousa RH, Araújo IG et al. Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats - A time course study. Endocrinology. 2007 Oct 1;148(10):4786-4792. https://doi.org/10.1210/en.2007-0043
Olivares, Emerson L. ; Marassi, Michelle P. ; Fortunato, Rodrigo S. ; Da Silva, Alba C M ; Costa-E-Sousa, Ricardo H. ; Araújo, Iracema G. ; Mattos, Elisabete C. ; Masuda, Masako O. ; Mulcahey, Michelle A. ; Huang, Stephen A. ; Bianco, Antonio C. ; Carvalho, Denise P. / Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats - A time course study. In: Endocrinology. 2007 ; Vol. 148, No. 10. pp. 4786-4792.
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