Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats - A time course study

Emerson L. Olivares, Michelle P. Marassi, Rodrigo S. Fortunato, Alba C.M. Da Silva, Ricardo H. Costa-E-Sousa, Iracema G. Araújo, Elisabete C. Mattos, Masako O. Masuda, Michelle A. Mulcahey, Stephen A. Huang, Antonio C. Bianco, Denise P. Carvalho

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99 Scopus citations

Abstract

In humans, there is a significant decrease in serum T3 and increase in rT3 at different time points after myocardial infarction, whereas serum TSH and T4 remain unaltered. We report here a time course study of pituitary-thyroid function and thyroid hormone metabolism in rats subjected to myocardial infarction by left coronary ligation (INF). INF- and sham-operated animals were followed by serial deiodination assays and thyroid function tests, just before, and 1, 4, 8, and 12 wk after surgery. At 4 and 12 wk after INF, liver type 1 deiodinase activity was significantly lower, confirming tissue hypothyroidism. Type 3 deiodinase (D3) activity was robustly induced 1 wk after INF only in the infarcted myocardium. Reminiscent of the consumptive hypothyroidism observed in patients with large D3-expressing tumors, this induction of cardiac D3 activity was associated with a decrease in both serum T4 (∼50% decrease) and T3 (37% decrease), despite compensatory stimulation of the thyroid. Thyroid stimulation was documented by both hyperthyrotropinemia and radioiodine uptake. Serum TSH increased by 4.3-fold in the first and 3.1-fold in the fourth weeks (P < 0.01), returning to the basal levels thereafter. Thyroid sodium/iodide-symporter function increased 1 wk after INF, accompanying the increased serum TSH. We conclude that the acute decrease in serum T4 and T3 after INF is due to increased thyroid hormone catabolism from ectopic D3 expression in the heart.

Original languageEnglish (US)
Pages (from-to)4786-4792
Number of pages7
JournalEndocrinology
Volume148
Issue number10
DOIs
StatePublished - Oct 1 2007

ASJC Scopus subject areas

  • Endocrinology

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    Olivares, E. L., Marassi, M. P., Fortunato, R. S., Da Silva, A. C. M., Costa-E-Sousa, R. H., Araújo, I. G., Mattos, E. C., Masuda, M. O., Mulcahey, M. A., Huang, S. A., Bianco, A. C., & Carvalho, D. P. (2007). Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats - A time course study. Endocrinology, 148(10), 4786-4792. https://doi.org/10.1210/en.2007-0043