Thymoxamine reverses phenylephrine-induced mydriasis

Susan J. Relf, N. Ziai Gharagozloo, Gregory L. Skuta, Wallace L.M. Alward, Douglas R. Anderson, Richard F. Brubaker

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


We performed a randomized double-masked evaluation of the alpha-adrenergic blocking agent thymoxamine (0.1%) as compared to placebo for the reversal of phenylephrineinduced mydriasis. Topically applied thymoxamine reversed the mydriasis from a single drop of 2.5% phenylephrine in 36 of 40 eyes (90%) within one hour. The mydriasis was completely reversed in 25 of 40 eyes (63%). Eyes with blue irides responded more quickly and more completely than did those with brown irides. The 40 contralateral eyes, which had also been dilated with phenylephrine, remained dilated or dilated further after receiving a placebo eyedrop. Twenty subjects (50%) reported mild transient ocular irritation upon instillation of thymoxamine. Thymoxamine was useful in individuals with narrow anterior chamber angles who were at risk of acute closed-angle glaucoma following dilation with an adrenergic agent.

Original languageEnglish (US)
Pages (from-to)251-255
Number of pages5
JournalAmerican journal of ophthalmology
Issue number15
StatePublished - Sep 15 1988

ASJC Scopus subject areas

  • Ophthalmology


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