TY - JOUR
T1 - Thymoxamine reverses phenylephrine-induced mydriasis
AU - Relf, Susan J.
AU - Gharagozloo, N. Ziai
AU - Skuta, Gregory L.
AU - Alward, Wallace L.M.
AU - Anderson, Douglas R.
AU - Brubaker, Richard F.
N1 - Funding Information:
This study was supported in part by National Institutes of Health research grant ROl EY 00634 (Dr. Brubaker); National Research Service Award T32 EY 07021 (Dr. Skuta); Research to Prevent Blindness, Inc.; IOLAB Pharmaceuticals, Claremont, California; National Glaucoma Research, a program of the American Health Assistance Foundation, Rockville, Maryland; and the Mayo Foundation, Rochester, Minnesota. This study was presented at the annual meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Florida, May 2, 1988.
PY - 1988/9/15
Y1 - 1988/9/15
N2 - We performed a randomized double-masked evaluation of the alpha-adrenergic blocking agent thymoxamine (0.1%) as compared to placebo for the reversal of phenylephrineinduced mydriasis. Topically applied thymoxamine reversed the mydriasis from a single drop of 2.5% phenylephrine in 36 of 40 eyes (90%) within one hour. The mydriasis was completely reversed in 25 of 40 eyes (63%). Eyes with blue irides responded more quickly and more completely than did those with brown irides. The 40 contralateral eyes, which had also been dilated with phenylephrine, remained dilated or dilated further after receiving a placebo eyedrop. Twenty subjects (50%) reported mild transient ocular irritation upon instillation of thymoxamine. Thymoxamine was useful in individuals with narrow anterior chamber angles who were at risk of acute closed-angle glaucoma following dilation with an adrenergic agent.
AB - We performed a randomized double-masked evaluation of the alpha-adrenergic blocking agent thymoxamine (0.1%) as compared to placebo for the reversal of phenylephrineinduced mydriasis. Topically applied thymoxamine reversed the mydriasis from a single drop of 2.5% phenylephrine in 36 of 40 eyes (90%) within one hour. The mydriasis was completely reversed in 25 of 40 eyes (63%). Eyes with blue irides responded more quickly and more completely than did those with brown irides. The 40 contralateral eyes, which had also been dilated with phenylephrine, remained dilated or dilated further after receiving a placebo eyedrop. Twenty subjects (50%) reported mild transient ocular irritation upon instillation of thymoxamine. Thymoxamine was useful in individuals with narrow anterior chamber angles who were at risk of acute closed-angle glaucoma following dilation with an adrenergic agent.
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U2 - 10.1016/0002-9394(88)90356-X
DO - 10.1016/0002-9394(88)90356-X
M3 - Article
C2 - 2971321
AN - SCOPUS:0023694967
VL - 106
SP - 251
EP - 255
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 15
ER -