Abstract
We performed a randomized double-masked evaluation of the alpha-adrenergic blocking agent thymoxamine (0.1%) as compared to placebo for the reversal of phenylephrineinduced mydriasis. Topically applied thymoxamine reversed the mydriasis from a single drop of 2.5% phenylephrine in 36 of 40 eyes (90%) within one hour. The mydriasis was completely reversed in 25 of 40 eyes (63%). Eyes with blue irides responded more quickly and more completely than did those with brown irides. The 40 contralateral eyes, which had also been dilated with phenylephrine, remained dilated or dilated further after receiving a placebo eyedrop. Twenty subjects (50%) reported mild transient ocular irritation upon instillation of thymoxamine. Thymoxamine was useful in individuals with narrow anterior chamber angles who were at risk of acute closed-angle glaucoma following dilation with an adrenergic agent.
| Original language | English |
|---|---|
| Pages (from-to) | 251-255 |
| Number of pages | 5 |
| Journal | American Journal of Ophthalmology |
| Volume | 106 |
| Issue number | 15 |
| DOIs | |
| State | Published - Sep 15 1988 |
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ASJC Scopus subject areas
- Ophthalmology
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Thymoxamine reverses phenylephrine-induced mydriasis. / Relf, Susan J.; Gharagozloo, N. Ziai; Skuta, Gregory L.; Alward, Wallace L M; Anderson, Douglas; Brubaker, Richard F.
In: American Journal of Ophthalmology, Vol. 106, No. 15, 15.09.1988, p. 251-255.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Thymoxamine reverses phenylephrine-induced mydriasis
AU - Relf, Susan J.
AU - Gharagozloo, N. Ziai
AU - Skuta, Gregory L.
AU - Alward, Wallace L M
AU - Anderson, Douglas
AU - Brubaker, Richard F.
PY - 1988/9/15
Y1 - 1988/9/15
N2 - We performed a randomized double-masked evaluation of the alpha-adrenergic blocking agent thymoxamine (0.1%) as compared to placebo for the reversal of phenylephrineinduced mydriasis. Topically applied thymoxamine reversed the mydriasis from a single drop of 2.5% phenylephrine in 36 of 40 eyes (90%) within one hour. The mydriasis was completely reversed in 25 of 40 eyes (63%). Eyes with blue irides responded more quickly and more completely than did those with brown irides. The 40 contralateral eyes, which had also been dilated with phenylephrine, remained dilated or dilated further after receiving a placebo eyedrop. Twenty subjects (50%) reported mild transient ocular irritation upon instillation of thymoxamine. Thymoxamine was useful in individuals with narrow anterior chamber angles who were at risk of acute closed-angle glaucoma following dilation with an adrenergic agent.
AB - We performed a randomized double-masked evaluation of the alpha-adrenergic blocking agent thymoxamine (0.1%) as compared to placebo for the reversal of phenylephrineinduced mydriasis. Topically applied thymoxamine reversed the mydriasis from a single drop of 2.5% phenylephrine in 36 of 40 eyes (90%) within one hour. The mydriasis was completely reversed in 25 of 40 eyes (63%). Eyes with blue irides responded more quickly and more completely than did those with brown irides. The 40 contralateral eyes, which had also been dilated with phenylephrine, remained dilated or dilated further after receiving a placebo eyedrop. Twenty subjects (50%) reported mild transient ocular irritation upon instillation of thymoxamine. Thymoxamine was useful in individuals with narrow anterior chamber angles who were at risk of acute closed-angle glaucoma following dilation with an adrenergic agent.
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U2 - 10.1016/0002-9394(88)90356-X
DO - 10.1016/0002-9394(88)90356-X
M3 - Article
C2 - 2971321
AN - SCOPUS:0023694967
VL - 106
SP - 251
EP - 255
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 15
ER -