Thymic irradiation inhibits the rapid recovery of TH1 but not TH2-Like functions of CD4+ T cells after total lymphoid irradiation

Hong Bass, Becky Adkins, Samuel Strober

Research output: Contribution to journalArticle

11 Scopus citations


Four to six weeks after total lymphoid irradiation (TL1), there is a selective deficit in the CD4+ T cells which secrete IL-2, proliferate in the MLR, and induce GVHD (Th1-like functions). A similar deficit in CD4+ T cells which secrete IL-4 and help antibody responses (Th2-like functions) is not observed. In the present study, shielding of the thymus with lead during TLI increased the Th1-like functions of CD4+ cells. Mice without thymus shields showed a marked selective reduction in the medullary stromal cells identified with the monoclonal antibody, MD1, and the severe reduction was prevented with thymus shields. Thus, shielding the thymus prevents the depletion of thymic medullary stromal cells and allows for a rapid recovery of Th1-like functions in the mouse spleen after TLI. Th2-like functions recover rapidly after TLI whether or not the thymus is irradiated.

Original languageEnglish (US)
Pages (from-to)316-328
Number of pages13
JournalCellular Immunology
Issue number2
StatePublished - Oct 15 1991


ASJC Scopus subject areas

  • Immunology

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