Thymic atrophy induced by murine mammary adenocarcinoma in vivo

Y. Fu, N. Altman, Diana M Lopez

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The thymic compartment of mammary tumor bearing mice is severely affected with increasing tumor growth. T cell functions in peripheral organs are greatly impaired or absent in such animals. A study of the thymus in relation to tumorigenesis revealed a profound decrease in size accompanied by a disrupture of the normal thymic architecture. Although a strong splenic suppressor cell activity can be detected in this animal model, splenectomy did not prevent thymic involution. Injection of tumor associated factors into normal mice resulted in a thymic atrophy similar to that seen in tumor bearing mice. These findings indicate that the observed thymic involution may not be only due to stress-related phenomena but also a direct effect of the tumor.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalIn Vivo
Volume3
Issue number1
StatePublished - Jan 1 1989

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Atrophy
Tumors
Adenocarcinoma
Breast
Bearings (structural)
Neoplasms
Animals
Splenectomy
Thymus
T-cells
Thymus Gland
Carcinogenesis
Animal Models
Breast Neoplasms
T-Lymphocytes
Injections
Growth

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Thymic atrophy induced by murine mammary adenocarcinoma in vivo. / Fu, Y.; Altman, N.; Lopez, Diana M.

In: In Vivo, Vol. 3, No. 1, 01.01.1989, p. 1-6.

Research output: Contribution to journalArticle

Fu, Y. ; Altman, N. ; Lopez, Diana M. / Thymic atrophy induced by murine mammary adenocarcinoma in vivo. In: In Vivo. 1989 ; Vol. 3, No. 1. pp. 1-6.
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