Thrombotic thrombocytopenic purpura as the cause of death in an HIV-positive child

Merce Jorda, Maria M. Rodriguez, Rita A. Reik

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A case of fatal thrombotic thrombocytopenic purpura (TTP) in a pediatric patient with HIV infection is reported. The diagnosis was made at autopsy based on the presence of platelet microthrombi in multiple organs, including the cardiac conduction system. The disease presented atypically with hemorrhagic manifestations, thrombocytopenia, and hemolytic anemia, without significant accompanying neurologic and renal abnormalities. Autoimmune-based thrombocytopenia has been well documented in the presence of HIV infection in both the adult and the pediatric population. We believe this to be the first reported case of TTP in an HIV-positive child..

Original languageEnglish (US)
Pages (from-to)919-925
Number of pages7
JournalFetal and Pediatric Pathology
Issue number6
StatePublished - 1994


  • DIC
  • HUS
  • ITP
  • Microangiopathic hemolytic anemia
  • Pediatric AIDS
  • Pediatric HIV
  • Thrombocytopenia
  • TTP

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Pediatrics, Perinatology, and Child Health


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