Thrombotic microangiopathies associated with drugs and bone marrow transplantation

J. L. Moake, J. J. Byrnes

Research output: Contribution to journalArticle

81 Scopus citations


This type of thrombotic microangiopathy more commonly resembles the hemolytic-uremic syndrome (HUS) than thrombotic thrombocytopenic purpura (TTP). The syndrome has been associated with the use of cyclosporin, mitomycin C, combinations of other chemotherapeutic and immunosuppressive agents, and total body irradiation. Endothelial cell injury and von Willebrand factor may be involved in pathogenesis of the intravascular platelet aggregation and tissue (especially renal) ischemia and infarction that characterize the entity. The most effective therapy for thrombotic microangiopathy associated with drugs and bone marrow transplantation has not been determined.

Original languageEnglish (US)
Pages (from-to)485-497
Number of pages13
JournalHematology/Oncology Clinics of North America
Issue number2
StatePublished - Jan 1 1996
Externally publishedYes


ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this