Thrombosis following desmopressin for uremic bleeding

John Byrnes, A. Larcada, J. L. Moake

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

An elderly patient with evidence of atherosclerosis and uremic bleeding diathesis developed two foci of cerebral thrombosis immediately after an infusion of desmopressin (DDAVP). Because large molecular weight multimers of von Willebrand factor (vWF) have been demonstrated to cause platelet aggregation under conditions of elevated fluid shear stress as occurs in atherosclerotic vessels, we investigated his plasma vWF at the time of the event and compared it to baseline values obtained 2 weeks later. Unusually large vWF multimers induced by the DDAVP infusion were present and likely contributed to the thrombotic process. Consequently, we believe DDAVP should be given with greater caution to patients with atherosclerosis.

Original languageEnglish
Pages (from-to)63-65
Number of pages3
JournalAmerican Journal of Hematology
Volume28
Issue number1
StatePublished - Jan 1 1988

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Deamino Arginine Vasopressin
von Willebrand Factor
Thrombosis
Hemorrhage
Atherosclerosis
Intracranial Thrombosis
Disease Susceptibility
Platelet Aggregation
Molecular Weight

ASJC Scopus subject areas

  • Hematology

Cite this

Thrombosis following desmopressin for uremic bleeding. / Byrnes, John; Larcada, A.; Moake, J. L.

In: American Journal of Hematology, Vol. 28, No. 1, 01.01.1988, p. 63-65.

Research output: Contribution to journalArticle

Byrnes, J, Larcada, A & Moake, JL 1988, 'Thrombosis following desmopressin for uremic bleeding', American Journal of Hematology, vol. 28, no. 1, pp. 63-65.
Byrnes, John ; Larcada, A. ; Moake, J. L. / Thrombosis following desmopressin for uremic bleeding. In: American Journal of Hematology. 1988 ; Vol. 28, No. 1. pp. 63-65.
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