Thrombocytopenia and thrombocytosis at time of hospitalization predict mortality in patients with community-acquired pneumonia

Mehdi Mirsaeidi, Paula Peyrani, Stefano Aliberti, Giovanni Filardo, Jose Bordon, Francesco Blasi, Julio A. Ramirez

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Background: Platelets are inflammatory cells with an important role in antimicrobial host defenses. We speculate that an abnormal platelet count may be a marker of severity in patients with community-acquired pneumonia (CAP). The objectives of this study were to evaluate if abnormal platelet count in hospitalized patients with CAP was associated with 30-day mortality and to compare platelet count and leukocyte count as predictors of 30-day mortality. Methods: We performed a retrospective cohort study of 500 consecutive patients hospitalized with CAP at the Veterans Hospital of Louisville, Kentucky, between June 2001 and March 2006 to investigate the association of platelet count and leukocyte count with 30-day mortality. Predictor variables were platelet count and leukocyte count. Abnormal platelet count was <100,000/L (thrombocytopenia) and > 400,000/L (thrombocytosis). The outcome variable was 30-day mortality. To control for potential confounding, a propensity score that incorporated 33 variables was used. Results: Platelet count was strongly associated ( P = .0009) with 30-day mortality, whereas no association was observed for leukocyte count ( P = .5114). High platelet counts resulted in a significantly increased risk of mortality. Conclusions: Thrombocytopenia and thrombocytosis are associated with mortality in patients hospitalized with CAP. When evaluating an initial CBC test in patients with CAP, an abnormal platelet count is a better predictor of outcome than an abnormal leukocyte count.

Original languageEnglish (US)
Pages (from-to)416-420
Number of pages5
JournalChest
Volume137
Issue number2
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

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Thrombocytosis
Platelet Count
Thrombocytopenia
Pneumonia
Hospitalization
Mortality
Leukocyte Count
Veterans Hospitals
Propensity Score
Cohort Studies
Blood Platelets
Retrospective Studies

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Thrombocytopenia and thrombocytosis at time of hospitalization predict mortality in patients with community-acquired pneumonia. / Mirsaeidi, Mehdi; Peyrani, Paula; Aliberti, Stefano; Filardo, Giovanni; Bordon, Jose; Blasi, Francesco; Ramirez, Julio A.

In: Chest, Vol. 137, No. 2, 01.02.2010, p. 416-420.

Research output: Contribution to journalArticle

Mirsaeidi, Mehdi ; Peyrani, Paula ; Aliberti, Stefano ; Filardo, Giovanni ; Bordon, Jose ; Blasi, Francesco ; Ramirez, Julio A. / Thrombocytopenia and thrombocytosis at time of hospitalization predict mortality in patients with community-acquired pneumonia. In: Chest. 2010 ; Vol. 137, No. 2. pp. 416-420.
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AU - Bordon, Jose

AU - Blasi, Francesco

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