Threshold values of high-risk echocardiographic epicardial fat thickness

Gianluca Iacobellis, Howard J. Willens, Giuseppe Barbaro, Arya M. Sharma

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

Objective:Echocardiographic epicardial adipose tissue is a new index of cardiac and visceral adiposity with great potential as a diagnostic tool and therapeutic target. In this study, we sought to provide threshold values of echocardiographic epicardial fat thickness associated with metabolic and anthropometric risk factors.Methods and Procedures:Epicardial fat thickness was measured in 246 consecutive white subjects (120 women, 126 men, median age 46 years (30-65), median BMI 32 kg/m2 (22-52), median waist circumference 100.5 cm (85-140)), who underwent routine transthoracic echocardiogram for standard clinical indications. Metabolic syndrome (MetS), Insulin resistance, BMI, and waist circumference categories were identified and epicardial fat was calculated.Results:Among 246 subjects, 58 had MetS. These subjects showed median values of epicardial fat thickness of 9.5 and 7.5 mm (in men and women, respectively), significantly higher than those found in subjects without MetS (no MetS) (P < 0.001). Receiver operating characteristics (ROC) analysis showed that epicardial fat thickness of 9.5 and 7.5 mm maximize the sensitivity and specificity to predict MetS, in men and women, respectively. In separate analyses, median epicardial fat thickness values of 9.5 and 7.5 mm were cutoff points associated with high abdominal fat in men and women, respectively. When insulin sensitivity was considered separately, epicardial fat thickness of 9.5 mm was associated with insulin resistance.Discussion:Median values of 9.5 and 7.5 mm should be considered the threshold values for high-risk echocardiographic epicardial fat thickness in white men and women, respectively. Echocardiographic epicardial fat measurement may be of help for cardiometabolic risk stratification and therapeutic interventions targeting the fat.

Original languageEnglish
Pages (from-to)887-892
Number of pages6
JournalObesity
Volume16
Issue number4
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

Fingerprint

Fats
Insulin Resistance
Waist Circumference
Abdominal Fat
Adiposity
ROC Curve
Adipose Tissue
Sensitivity and Specificity
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Threshold values of high-risk echocardiographic epicardial fat thickness. / Iacobellis, Gianluca; Willens, Howard J.; Barbaro, Giuseppe; Sharma, Arya M.

In: Obesity, Vol. 16, No. 4, 01.04.2008, p. 887-892.

Research output: Contribution to journalArticle

Iacobellis, Gianluca ; Willens, Howard J. ; Barbaro, Giuseppe ; Sharma, Arya M. / Threshold values of high-risk echocardiographic epicardial fat thickness. In: Obesity. 2008 ; Vol. 16, No. 4. pp. 887-892.
@article{e2110f095d3e4f6cb66706c1ec648104,
title = "Threshold values of high-risk echocardiographic epicardial fat thickness",
abstract = "Objective:Echocardiographic epicardial adipose tissue is a new index of cardiac and visceral adiposity with great potential as a diagnostic tool and therapeutic target. In this study, we sought to provide threshold values of echocardiographic epicardial fat thickness associated with metabolic and anthropometric risk factors.Methods and Procedures:Epicardial fat thickness was measured in 246 consecutive white subjects (120 women, 126 men, median age 46 years (30-65), median BMI 32 kg/m2 (22-52), median waist circumference 100.5 cm (85-140)), who underwent routine transthoracic echocardiogram for standard clinical indications. Metabolic syndrome (MetS), Insulin resistance, BMI, and waist circumference categories were identified and epicardial fat was calculated.Results:Among 246 subjects, 58 had MetS. These subjects showed median values of epicardial fat thickness of 9.5 and 7.5 mm (in men and women, respectively), significantly higher than those found in subjects without MetS (no MetS) (P < 0.001). Receiver operating characteristics (ROC) analysis showed that epicardial fat thickness of 9.5 and 7.5 mm maximize the sensitivity and specificity to predict MetS, in men and women, respectively. In separate analyses, median epicardial fat thickness values of 9.5 and 7.5 mm were cutoff points associated with high abdominal fat in men and women, respectively. When insulin sensitivity was considered separately, epicardial fat thickness of 9.5 mm was associated with insulin resistance.Discussion:Median values of 9.5 and 7.5 mm should be considered the threshold values for high-risk echocardiographic epicardial fat thickness in white men and women, respectively. Echocardiographic epicardial fat measurement may be of help for cardiometabolic risk stratification and therapeutic interventions targeting the fat.",
author = "Gianluca Iacobellis and Willens, {Howard J.} and Giuseppe Barbaro and Sharma, {Arya M.}",
year = "2008",
month = "4",
day = "1",
doi = "10.1038/oby.2008.6",
language = "English",
volume = "16",
pages = "887--892",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Threshold values of high-risk echocardiographic epicardial fat thickness

AU - Iacobellis, Gianluca

AU - Willens, Howard J.

AU - Barbaro, Giuseppe

AU - Sharma, Arya M.

PY - 2008/4/1

Y1 - 2008/4/1

N2 - Objective:Echocardiographic epicardial adipose tissue is a new index of cardiac and visceral adiposity with great potential as a diagnostic tool and therapeutic target. In this study, we sought to provide threshold values of echocardiographic epicardial fat thickness associated with metabolic and anthropometric risk factors.Methods and Procedures:Epicardial fat thickness was measured in 246 consecutive white subjects (120 women, 126 men, median age 46 years (30-65), median BMI 32 kg/m2 (22-52), median waist circumference 100.5 cm (85-140)), who underwent routine transthoracic echocardiogram for standard clinical indications. Metabolic syndrome (MetS), Insulin resistance, BMI, and waist circumference categories were identified and epicardial fat was calculated.Results:Among 246 subjects, 58 had MetS. These subjects showed median values of epicardial fat thickness of 9.5 and 7.5 mm (in men and women, respectively), significantly higher than those found in subjects without MetS (no MetS) (P < 0.001). Receiver operating characteristics (ROC) analysis showed that epicardial fat thickness of 9.5 and 7.5 mm maximize the sensitivity and specificity to predict MetS, in men and women, respectively. In separate analyses, median epicardial fat thickness values of 9.5 and 7.5 mm were cutoff points associated with high abdominal fat in men and women, respectively. When insulin sensitivity was considered separately, epicardial fat thickness of 9.5 mm was associated with insulin resistance.Discussion:Median values of 9.5 and 7.5 mm should be considered the threshold values for high-risk echocardiographic epicardial fat thickness in white men and women, respectively. Echocardiographic epicardial fat measurement may be of help for cardiometabolic risk stratification and therapeutic interventions targeting the fat.

AB - Objective:Echocardiographic epicardial adipose tissue is a new index of cardiac and visceral adiposity with great potential as a diagnostic tool and therapeutic target. In this study, we sought to provide threshold values of echocardiographic epicardial fat thickness associated with metabolic and anthropometric risk factors.Methods and Procedures:Epicardial fat thickness was measured in 246 consecutive white subjects (120 women, 126 men, median age 46 years (30-65), median BMI 32 kg/m2 (22-52), median waist circumference 100.5 cm (85-140)), who underwent routine transthoracic echocardiogram for standard clinical indications. Metabolic syndrome (MetS), Insulin resistance, BMI, and waist circumference categories were identified and epicardial fat was calculated.Results:Among 246 subjects, 58 had MetS. These subjects showed median values of epicardial fat thickness of 9.5 and 7.5 mm (in men and women, respectively), significantly higher than those found in subjects without MetS (no MetS) (P < 0.001). Receiver operating characteristics (ROC) analysis showed that epicardial fat thickness of 9.5 and 7.5 mm maximize the sensitivity and specificity to predict MetS, in men and women, respectively. In separate analyses, median epicardial fat thickness values of 9.5 and 7.5 mm were cutoff points associated with high abdominal fat in men and women, respectively. When insulin sensitivity was considered separately, epicardial fat thickness of 9.5 mm was associated with insulin resistance.Discussion:Median values of 9.5 and 7.5 mm should be considered the threshold values for high-risk echocardiographic epicardial fat thickness in white men and women, respectively. Echocardiographic epicardial fat measurement may be of help for cardiometabolic risk stratification and therapeutic interventions targeting the fat.

UR - http://www.scopus.com/inward/record.url?scp=41549158784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41549158784&partnerID=8YFLogxK

U2 - 10.1038/oby.2008.6

DO - 10.1038/oby.2008.6

M3 - Article

C2 - 18379565

AN - SCOPUS:41549158784

VL - 16

SP - 887

EP - 892

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 4

ER -