Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

Tadaaki Miyazaki, Zhao-Jun Liu, Atsuo Kawahara, Yasuhiro Minami, Kyoko Yamada, Yoshihide Tsujimoto, Edward L. Barsoumian, Roger M. Perlmutter, Tadatsugu Taniguchi

Research output: Contribution to journalArticle

338 Citations (Scopus)

Abstract

Two interleukin-2 receptor-dependent signaling pathways have thus far been identified: the c-fos/c-jun induction pathway mediated by src family protein-tyrosine kinases and the c-myc induction pathway. Here, we provide evidence for the existence of a third, rapamycin-sensitive pathway, which- results in the induction of another proto-oncogene, bcl-2. In the hematopoietic cell line BAF-1303, the expression of any two of lckF505 (an active form of [56lck), Bcl-2, or c-Myc is sufficient to promote transit of the cell cycle, regardless of the activation state of the third pathway. We also provide evidence that epidermal growth factor receptor signaling may act through the same pathway that involves [56lck. These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation.

Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalCell
Volume81
Issue number2
DOIs
StatePublished - Apr 21 1995
Externally publishedYes

Fingerprint

src-Family Kinases
Cell proliferation
Interleukin-2
Cell Proliferation
Proto-Oncogenes
Interleukin-2 Receptors
Sirolimus
Cells
Epidermal Growth Factor Receptor
Cell Cycle
Cell Line
Protein-Tyrosine Kinases
Chemical activation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology
  • Molecular Biology

Cite this

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. / Miyazaki, Tadaaki; Liu, Zhao-Jun; Kawahara, Atsuo; Minami, Yasuhiro; Yamada, Kyoko; Tsujimoto, Yoshihide; Barsoumian, Edward L.; Perlmutter, Roger M.; Taniguchi, Tadatsugu.

In: Cell, Vol. 81, No. 2, 21.04.1995, p. 223-231.

Research output: Contribution to journalArticle

Miyazaki, T, Liu, Z-J, Kawahara, A, Minami, Y, Yamada, K, Tsujimoto, Y, Barsoumian, EL, Perlmutter, RM & Taniguchi, T 1995, 'Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation', Cell, vol. 81, no. 2, pp. 223-231. https://doi.org/10.1016/0092-8674(95)90332-1
Miyazaki, Tadaaki ; Liu, Zhao-Jun ; Kawahara, Atsuo ; Minami, Yasuhiro ; Yamada, Kyoko ; Tsujimoto, Yoshihide ; Barsoumian, Edward L. ; Perlmutter, Roger M. ; Taniguchi, Tadatsugu. / Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. In: Cell. 1995 ; Vol. 81, No. 2. pp. 223-231.
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