Abstract
Two interleukin-2 receptor-dependent signaling pathways have thus far been identified: the c-fos/c-jun induction pathway mediated by src family protein-tyrosine kinases and the c-myc induction pathway. Here, we provide evidence for the existence of a third, rapamycin-sensitive pathway, which- results in the induction of another proto-oncogene, bcl-2. In the hematopoietic cell line BAF-1303, the expression of any two of lckF505 (an active form of [56lck), Bcl-2, or c-Myc is sufficient to promote transit of the cell cycle, regardless of the activation state of the third pathway. We also provide evidence that epidermal growth factor receptor signaling may act through the same pathway that involves [56lck. These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation.
| Original language | English |
|---|---|
| Pages (from-to) | 223-231 |
| Number of pages | 9 |
| Journal | Cell |
| Volume | 81 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 21 1995 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
- Molecular Biology
Cite this
Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. / Miyazaki, Tadaaki; Liu, Zhao-Jun; Kawahara, Atsuo; Minami, Yasuhiro; Yamada, Kyoko; Tsujimoto, Yoshihide; Barsoumian, Edward L.; Perlmutter, Roger M.; Taniguchi, Tadatsugu.
In: Cell, Vol. 81, No. 2, 21.04.1995, p. 223-231.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation
AU - Miyazaki, Tadaaki
AU - Liu, Zhao-Jun
AU - Kawahara, Atsuo
AU - Minami, Yasuhiro
AU - Yamada, Kyoko
AU - Tsujimoto, Yoshihide
AU - Barsoumian, Edward L.
AU - Perlmutter, Roger M.
AU - Taniguchi, Tadatsugu
PY - 1995/4/21
Y1 - 1995/4/21
N2 - Two interleukin-2 receptor-dependent signaling pathways have thus far been identified: the c-fos/c-jun induction pathway mediated by src family protein-tyrosine kinases and the c-myc induction pathway. Here, we provide evidence for the existence of a third, rapamycin-sensitive pathway, which- results in the induction of another proto-oncogene, bcl-2. In the hematopoietic cell line BAF-1303, the expression of any two of lckF505 (an active form of [56lck), Bcl-2, or c-Myc is sufficient to promote transit of the cell cycle, regardless of the activation state of the third pathway. We also provide evidence that epidermal growth factor receptor signaling may act through the same pathway that involves [56lck. These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation.
AB - Two interleukin-2 receptor-dependent signaling pathways have thus far been identified: the c-fos/c-jun induction pathway mediated by src family protein-tyrosine kinases and the c-myc induction pathway. Here, we provide evidence for the existence of a third, rapamycin-sensitive pathway, which- results in the induction of another proto-oncogene, bcl-2. In the hematopoietic cell line BAF-1303, the expression of any two of lckF505 (an active form of [56lck), Bcl-2, or c-Myc is sufficient to promote transit of the cell cycle, regardless of the activation state of the third pathway. We also provide evidence that epidermal growth factor receptor signaling may act through the same pathway that involves [56lck. These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation.
UR - http://www.scopus.com/inward/record.url?scp=0029054455&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029054455&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(95)90332-1
DO - 10.1016/0092-8674(95)90332-1
M3 - Article
VL - 81
SP - 223
EP - 231
JO - Cell
JF - Cell
SN - 0092-8674
IS - 2
ER -