Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

Tadaaki Miyazaki, Zhao Jun Liu, Atsuo Kawahara, Yasuhiro Minami, Kyoko Yamada, Yoshihide Tsujimoto, Edward L. Barsoumian, Roger M. Perlmutter, Tadatsugu Taniguchi

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342 Scopus citations

Abstract

Two interleukin-2 receptor-dependent signaling pathways have thus far been identified: the c-fos/c-jun induction pathway mediated by src family protein-tyrosine kinases and the c-myc induction pathway. Here, we provide evidence for the existence of a third, rapamycin-sensitive pathway, which- results in the induction of another proto-oncogene, bcl-2. In the hematopoietic cell line BAF-1303, the expression of any two of lckF505 (an active form of [56lck), Bcl-2, or c-Myc is sufficient to promote transit of the cell cycle, regardless of the activation state of the third pathway. We also provide evidence that epidermal growth factor receptor signaling may act through the same pathway that involves [56lck. These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation.

Original languageEnglish (US)
Pages (from-to)223-231
Number of pages9
JournalCell
Volume81
Issue number2
DOIs
StatePublished - Apr 21 1995

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Miyazaki, T., Liu, Z. J., Kawahara, A., Minami, Y., Yamada, K., Tsujimoto, Y., Barsoumian, E. L., Perlmutter, R. M., & Taniguchi, T. (1995). Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell, 81(2), 223-231. https://doi.org/10.1016/0092-8674(95)90332-1