TY - JOUR
T1 - Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation
AU - Miyazaki, Tadaaki
AU - Liu, Zhao Jun
AU - Kawahara, Atsuo
AU - Minami, Yasuhiro
AU - Yamada, Kyoko
AU - Tsujimoto, Yoshihide
AU - Barsoumian, Edward L.
AU - Perlmutter, Roger M.
AU - Taniguchi, Tadatsugu
N1 - Funding Information:
We thank Drs. S. Korsmeyer, G. Thompson, and T. Kondo for providing us with the bax, bcl-xL and N-myc cDNAs, Dr. A. P. Baker and Fujisawa Chemical for RAP and FK506. We also thank Dr. A. Kukula for critical reading of the manuscript and Drs. M. Lamphier and Y. Eguchi for valuable comments. This work was supported in part by a Grant in Aid for Special Project Research, Cancer Bioscience, from the Ministry of Education, Science, and Culture of Japan. The first two authors contributed equally to this work.
PY - 1995/4/21
Y1 - 1995/4/21
N2 - Two interleukin-2 receptor-dependent signaling pathways have thus far been identified: the c-fos/c-jun induction pathway mediated by src family protein-tyrosine kinases and the c-myc induction pathway. Here, we provide evidence for the existence of a third, rapamycin-sensitive pathway, which- results in the induction of another proto-oncogene, bcl-2. In the hematopoietic cell line BAF-1303, the expression of any two of lckF505 (an active form of [56lck), Bcl-2, or c-Myc is sufficient to promote transit of the cell cycle, regardless of the activation state of the third pathway. We also provide evidence that epidermal growth factor receptor signaling may act through the same pathway that involves [56lck. These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation.
AB - Two interleukin-2 receptor-dependent signaling pathways have thus far been identified: the c-fos/c-jun induction pathway mediated by src family protein-tyrosine kinases and the c-myc induction pathway. Here, we provide evidence for the existence of a third, rapamycin-sensitive pathway, which- results in the induction of another proto-oncogene, bcl-2. In the hematopoietic cell line BAF-1303, the expression of any two of lckF505 (an active form of [56lck), Bcl-2, or c-Myc is sufficient to promote transit of the cell cycle, regardless of the activation state of the third pathway. We also provide evidence that epidermal growth factor receptor signaling may act through the same pathway that involves [56lck. These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation.
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U2 - 10.1016/0092-8674(95)90332-1
DO - 10.1016/0092-8674(95)90332-1
M3 - Article
C2 - 7736574
AN - SCOPUS:0029054455
VL - 81
SP - 223
EP - 231
JO - Cell
JF - Cell
SN - 0092-8674
IS - 2
ER -