Abstract
Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 965-974 |
| Number of pages | 10 |
| Journal | Magnetic Resonance Imaging |
| Volume | 10 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
Keywords
- H spectroscopy
- Metabolite mapping
- Rat brain
- Spectroscopic imaging
- Surface coil
ASJC Scopus subject areas
- Biophysics
- Clinical Biochemistry
- Structural Biology
- Radiology Nuclear Medicine and imaging
- Condensed Matter Physics
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Fernandez, E. J., Maudsley, A. A., Higuchi, T., & Weiner, M. W. (1992). Three-dimensional 1H spectroscopic imaging of cerebral metabolites in the rat using surface coils. Magnetic Resonance Imaging, 10(6), 965-974. https://doi.org/10.1016/0730-725X(92)90451-5