Three-dimensional 1H spectroscopic imaging of cerebral metabolites in the rat using surface coils

E. J. Fernandez, A. A. Maudsley, T. Higuchi, M. W. Weiner

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.

Original languageEnglish (US)
Pages (from-to)965-974
Number of pages10
JournalMagnetic Resonance Imaging
Volume10
Issue number6
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • H spectroscopy
  • Metabolite mapping
  • Rat brain
  • Spectroscopic imaging
  • Surface coil

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

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