Abstract
Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.
| Original language | English |
|---|---|
| Pages (from-to) | 965-974 |
| Number of pages | 10 |
| Journal | Magnetic Resonance Imaging |
| Volume | 10 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1992 |
| Externally published | Yes |
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Keywords
- H spectroscopy
- Metabolite mapping
- Rat brain
- Spectroscopic imaging
- Surface coil
ASJC Scopus subject areas
- Biophysics
- Clinical Biochemistry
- Structural Biology
- Radiology Nuclear Medicine and imaging
- Condensed Matter Physics
Cite this
Three-dimensional 1H spectroscopic imaging of cerebral metabolites in the rat using surface coils. / Fernandez, E. J.; Maudsley, Andrew A; Higuchi, T.; Weiner, M. W.
In: Magnetic Resonance Imaging, Vol. 10, No. 6, 01.01.1992, p. 965-974.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Three-dimensional 1H spectroscopic imaging of cerebral metabolites in the rat using surface coils
AU - Fernandez, E. J.
AU - Maudsley, Andrew A
AU - Higuchi, T.
AU - Weiner, M. W.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.
AB - Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.
KW - H spectroscopy
KW - Metabolite mapping
KW - Rat brain
KW - Spectroscopic imaging
KW - Surface coil
UR - http://www.scopus.com/inward/record.url?scp=0027008437&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027008437&partnerID=8YFLogxK
U2 - 10.1016/0730-725X(92)90451-5
DO - 10.1016/0730-725X(92)90451-5
M3 - Article
C2 - 1461094
AN - SCOPUS:0027008437
VL - 10
SP - 965
EP - 974
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
IS - 6
ER -