Three-dimensional 1H spectroscopic imaging of cerebral metabolites in the rat using surface coils

E. J. Fernandez; A. A. Maudsley; T. Higuchi; M. W. Weiner

doi:10.1016/0730-725X(92)90451-5

Three-dimensional ¹H spectroscopic imaging of cerebral metabolites in the rat using surface coils

E. J. Fernandez, A. A. Maudsley, T. Higuchi, M. W. Weiner

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Three dimensional metabolite maps of protonated metabolites were obtained using ¹H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B₁ excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.

Original language	English (US)
Pages (from-to)	965-974
Number of pages	10
Journal	Magnetic Resonance Imaging
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/0730-725X(92)90451-5
State	Published - 1992
Externally published	Yes

Keywords

H spectroscopy
Metabolite mapping
Rat brain
Spectroscopic imaging
Surface coil

ASJC Scopus subject areas

Biophysics
Clinical Biochemistry
Structural Biology
Radiology Nuclear Medicine and imaging
Condensed Matter Physics

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10.1016/0730-725X(92)90451-5

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@article{5ecd746b1a99460a89ca0bee26b53243,

title = "Three-dimensional 1H spectroscopic imaging of cerebral metabolites in the rat using surface coils",

abstract = "Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.",

keywords = "H spectroscopy, Metabolite mapping, Rat brain, Spectroscopic imaging, Surface coil",

author = "Fernandez, {E. J.} and Maudsley, {A. A.} and T. Higuchi and Weiner, {M. W.}",

note = "Funding Information: Acknowledgment-This work was supportedb y PHS grants ROI-CA48815, ROI-DK33293, and HL-07192-14, the Veterans Administration Medical Research Service, and Meiji College of Oriental Medicine, Kyoto, Japan.",

year = "1992",

doi = "10.1016/0730-725X(92)90451-5",

language = "English (US)",

volume = "10",

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journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

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T1 - Three-dimensional 1H spectroscopic imaging of cerebral metabolites in the rat using surface coils

AU - Fernandez, E. J.

AU - Maudsley, A. A.

AU - Higuchi, T.

AU - Weiner, M. W.

N1 - Funding Information: Acknowledgment-This work was supportedb y PHS grants ROI-CA48815, ROI-DK33293, and HL-07192-14, the Veterans Administration Medical Research Service, and Meiji College of Oriental Medicine, Kyoto, Japan.

PY - 1992

Y1 - 1992

N2 - Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.

AB - Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.

KW - H spectroscopy

KW - Metabolite mapping

KW - Rat brain

KW - Spectroscopic imaging

KW - Surface coil

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