Three-dimensional 1H spectroscopic imaging of cerebral metabolites in the rat using surface coils

E. J. Fernandez; A. A. Maudsley; T. Higuchi; M. W. Weiner

doi:10.1016/0730-725X(92)90451-5

Three-dimensional ¹H spectroscopic imaging of cerebral metabolites in the rat using surface coils

E. J. Fernandez, A. A. Maudsley, T. Higuchi, M. W. Weiner

Radiology

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

Three dimensional metabolite maps of protonated metabolites were obtained using ¹H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B₁ excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.

Original language	English (US)
Pages (from-to)	965-974
Number of pages	10
Journal	Magnetic Resonance Imaging
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/0730-725X(92)90451-5
State	Published - 1992

Fingerprint

Keywords

H spectroscopy
Metabolite mapping
Rat brain
Spectroscopic imaging
Surface coil

ASJC Scopus subject areas

Biophysics
Clinical Biochemistry
Structural Biology
Radiology Nuclear Medicine and imaging
Condensed Matter Physics

Cite this

Fernandez, E. J., Maudsley, A. A., Higuchi, T., & Weiner, M. W. (1992). Three-dimensional ¹H spectroscopic imaging of cerebral metabolites in the rat using surface coils. Magnetic Resonance Imaging, 10(6), 965-974. https://doi.org/10.1016/0730-725X(92)90451-5

@article{5ecd746b1a99460a89ca0bee26b53243,

title = "Three-dimensional 1H spectroscopic imaging of cerebral metabolites in the rat using surface coils",

abstract = "Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.",

keywords = "H spectroscopy, Metabolite mapping, Rat brain, Spectroscopic imaging, Surface coil",

author = "Fernandez, {E. J.} and Maudsley, {A. A.} and T. Higuchi and Weiner, {M. W.}",

year = "1992",

doi = "10.1016/0730-725X(92)90451-5",

language = "English (US)",

volume = "10",

pages = "965--974",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Three-dimensional 1H spectroscopic imaging of cerebral metabolites in the rat using surface coils

AU - Fernandez, E. J.

AU - Maudsley, A. A.

AU - Higuchi, T.

AU - Weiner, M. W.

PY - 1992

Y1 - 1992

N2 - Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.

AB - Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.

KW - H spectroscopy

KW - Metabolite mapping

KW - Rat brain

KW - Spectroscopic imaging

KW - Surface coil

UR - http://www.scopus.com/inward/record.url?scp=0027008437&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027008437&partnerID=8YFLogxK

U2 - 10.1016/0730-725X(92)90451-5

DO - 10.1016/0730-725X(92)90451-5

M3 - Article

C2 - 1461094

AN - SCOPUS:0027008437

VL - 10

SP - 965

EP - 974

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

IS - 6

ER -

Access to Document

10.1016/0730-725X(92)90451-5