Three-dimensional inhomogeneous triphasic finite-element analysis of physical signals and solute transport in human intervertebral disc under axial compression

Hai Yao, Wei Yong Gu

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

A 3D inhomogeneous finite-element model for charged hydrated soft tissues containing charged/uncharged solutes was developed and applied to analyze the mechanical, chemical, and electrical signals within the human intervertebral disc during an axial unconfined compression. The effects of tissue properties and boundary conditions on the physical signals and the transport of fluid and solute were investigated. The numerical simulation showed that, during disc compression, the fluid pressurization and the effective (von Misses) solid stress were more pronounced in the annulus fibrosus (AF) region near the interface between AF and nucleus pulposus (NP). In NP, the distributions of the fluid pressure, effective stress, and electrical potential were more uniform than those in AF. The electrical signals were very sensitive to fixed charge density. Changes in material properties of NP (water content, fixed charge density, and modulus) affected fluid pressure, electrical potential, effective stress, and solute transport in the disc. This study is important for understanding disc biomechanics, disc nutrition, and disc mechanobiology.

Original languageEnglish (US)
Pages (from-to)2071-2077
Number of pages7
JournalJournal of Biomechanics
Volume40
Issue number9
DOIs
StatePublished - Jun 5 2007

Keywords

  • Finite-element method
  • Intervertebral disc
  • Soft tissue mechanics
  • Solute transport
  • Triphasic theory

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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