Abstract
A 3D inhomogeneous finite-element model for charged hydrated soft tissues containing charged/uncharged solutes was developed and applied to analyze the mechanical, chemical, and electrical signals within the human intervertebral disc during an axial unconfined compression. The effects of tissue properties and boundary conditions on the physical signals and the transport of fluid and solute were investigated. The numerical simulation showed that, during disc compression, the fluid pressurization and the effective (von Misses) solid stress were more pronounced in the annulus fibrosus (AF) region near the interface between AF and nucleus pulposus (NP). In NP, the distributions of the fluid pressure, effective stress, and electrical potential were more uniform than those in AF. The electrical signals were very sensitive to fixed charge density. Changes in material properties of NP (water content, fixed charge density, and modulus) affected fluid pressure, electrical potential, effective stress, and solute transport in the disc. This study is important for understanding disc biomechanics, disc nutrition, and disc mechanobiology.
| Original language | English |
|---|---|
| Pages (from-to) | 2071-2077 |
| Number of pages | 7 |
| Journal | Journal of Biomechanics |
| Volume | 40 |
| Issue number | 9 |
| DOIs | |
| State | Published - Jun 5 2007 |
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Keywords
- Finite-element method
- Intervertebral disc
- Soft tissue mechanics
- Solute transport
- Triphasic theory
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
Cite this
Three-dimensional inhomogeneous triphasic finite-element analysis of physical signals and solute transport in human intervertebral disc under axial compression. / Yao, Hai; Gu, Weiyong.
In: Journal of Biomechanics, Vol. 40, No. 9, 05.06.2007, p. 2071-2077.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Three-dimensional inhomogeneous triphasic finite-element analysis of physical signals and solute transport in human intervertebral disc under axial compression
AU - Yao, Hai
AU - Gu, Weiyong
PY - 2007/6/5
Y1 - 2007/6/5
N2 - A 3D inhomogeneous finite-element model for charged hydrated soft tissues containing charged/uncharged solutes was developed and applied to analyze the mechanical, chemical, and electrical signals within the human intervertebral disc during an axial unconfined compression. The effects of tissue properties and boundary conditions on the physical signals and the transport of fluid and solute were investigated. The numerical simulation showed that, during disc compression, the fluid pressurization and the effective (von Misses) solid stress were more pronounced in the annulus fibrosus (AF) region near the interface between AF and nucleus pulposus (NP). In NP, the distributions of the fluid pressure, effective stress, and electrical potential were more uniform than those in AF. The electrical signals were very sensitive to fixed charge density. Changes in material properties of NP (water content, fixed charge density, and modulus) affected fluid pressure, electrical potential, effective stress, and solute transport in the disc. This study is important for understanding disc biomechanics, disc nutrition, and disc mechanobiology.
AB - A 3D inhomogeneous finite-element model for charged hydrated soft tissues containing charged/uncharged solutes was developed and applied to analyze the mechanical, chemical, and electrical signals within the human intervertebral disc during an axial unconfined compression. The effects of tissue properties and boundary conditions on the physical signals and the transport of fluid and solute were investigated. The numerical simulation showed that, during disc compression, the fluid pressurization and the effective (von Misses) solid stress were more pronounced in the annulus fibrosus (AF) region near the interface between AF and nucleus pulposus (NP). In NP, the distributions of the fluid pressure, effective stress, and electrical potential were more uniform than those in AF. The electrical signals were very sensitive to fixed charge density. Changes in material properties of NP (water content, fixed charge density, and modulus) affected fluid pressure, electrical potential, effective stress, and solute transport in the disc. This study is important for understanding disc biomechanics, disc nutrition, and disc mechanobiology.
KW - Finite-element method
KW - Intervertebral disc
KW - Soft tissue mechanics
KW - Solute transport
KW - Triphasic theory
UR - http://www.scopus.com/inward/record.url?scp=34249650771&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249650771&partnerID=8YFLogxK
U2 - 10.1016/j.jbiomech.2006.10.001
DO - 10.1016/j.jbiomech.2006.10.001
M3 - Article
C2 - 17125776
AN - SCOPUS:34249650771
VL - 40
SP - 2071
EP - 2077
JO - Journal of Biomechanics
JF - Journal of Biomechanics
SN - 0021-9290
IS - 9
ER -