Three cases of acquired factor VIII

C inhibitors in non-hemophilic patients

D. Söhngen, W. Köster, B. M E Kuntz, S. Glück, W. Schneider

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

During the last ten years we observed three non-hemophilic patients with factor(F) VIII: C inhibitors (2 women aged 68 and 80 and a man aged 51). In all three cases, a sudden bleeding tendency was observed shortly after an injury or surgery. Coagulation tests showed a prolonged aPTT and a decreased F VIII: C level. Other deficiencies of blood-clotting factors and acquired or hereditary von Willebrand's disease could be excluded. Therapy with F VIII: C concentrate, cryoprecipitate, or fresh-frozen plasma did not produce the expected increase in F VIII: C. Measurement of F VIII: C inhibitor levels (Bethesda Units, BU) revealed values in the range between 9 and 64 BU. The two patients subjected to long-term therapy with a combination of prednisone (initially 2-3 mg/kg BW) and azathioprine (2-3 mg/kg BW) responded positively; the F VIII: C concentration increased. The third patient, treated only with a low dose of prednisone (30 mg/day), did not show any reaction at all. Since hereditary hemophilia A could be excluded, the inhibitors apparently were acquired. Malignant tumors did not appear. In conclusion, long-term therapy of an acquired F VIII: C inhibitor with a combination of prednisone and azathioprine may lead to complete disappearance of the inhibitor, normalization of the coagulation tests, and complete remission of the bleeding tendency.

Original languageEnglish
Pages (from-to)1071-1075
Number of pages5
JournalKlinische Wochenschrift
Volume68
Issue number21
DOIs
StatePublished - Nov 1 1990
Externally publishedYes

Fingerprint

Factor VIII
Prednisone
Azathioprine
Hemorrhage
von Willebrand Diseases
Blood Coagulation Factors
Hemophilia A
Blood Coagulation
Therapeutics
Wounds and Injuries

Keywords

  • Factor VIII: C inhibitors
  • Immunosuppressive therapy
  • Non-hemophiliacs

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Söhngen, D., Köster, W., Kuntz, B. M. E., Glück, S., & Schneider, W. (1990). Three cases of acquired factor VIII: C inhibitors in non-hemophilic patients. Klinische Wochenschrift, 68(21), 1071-1075. https://doi.org/10.1007/BF01649308

Three cases of acquired factor VIII : C inhibitors in non-hemophilic patients. / Söhngen, D.; Köster, W.; Kuntz, B. M E; Glück, S.; Schneider, W.

In: Klinische Wochenschrift, Vol. 68, No. 21, 01.11.1990, p. 1071-1075.

Research output: Contribution to journalArticle

Söhngen, D, Köster, W, Kuntz, BME, Glück, S & Schneider, W 1990, 'Three cases of acquired factor VIII: C inhibitors in non-hemophilic patients', Klinische Wochenschrift, vol. 68, no. 21, pp. 1071-1075. https://doi.org/10.1007/BF01649308
Söhngen D, Köster W, Kuntz BME, Glück S, Schneider W. Three cases of acquired factor VIII: C inhibitors in non-hemophilic patients. Klinische Wochenschrift. 1990 Nov 1;68(21):1071-1075. https://doi.org/10.1007/BF01649308
Söhngen, D. ; Köster, W. ; Kuntz, B. M E ; Glück, S. ; Schneider, W. / Three cases of acquired factor VIII : C inhibitors in non-hemophilic patients. In: Klinische Wochenschrift. 1990 ; Vol. 68, No. 21. pp. 1071-1075.
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