Thoracoabdominal compression and respiratory system compliance in HIV- infected infants

Arnold C.G. Platzker, Andrew A. Colin, Xin C. Chen, Peter Hiatt, Janice Hunter, Anatassios C. Koumbourlis, Mark D. Schluchter, Andrew Ting, Mary Ellen Wohl

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The thoracoabdominal compression technique (TAC) is used to measure expiratory flow in infants. We investigated whether TAC caused a change in total thoracic compliance (Crs), resistance (Rrs), and respiratory system time constant (Trs). We studied 41 infants (mean age, 12.4 mo; SD, 7.5) from five centers studying longitudinal lung and cardiovascular function of infants from HIV-infected mothers. We measured Crs, Rrs, and Trs before and after TAC. Changes in Crs, Rrs, and Trs after TAC were not dependent on the length of time since TAC. Crs and Trs were reduced after TAC, p = 0.013 and p = 0.003, respectively, whereas Rrs did not change. When compared with uninfected infants, HIV-infected infants had a larger post-pre TAC percent decline in Crs (p = 0.003) and a post-pre TAC rise in mean Rrs (p = 0.03). These differences remained significant after adjusting for sex and age. When performing infant pulmonary function testing, TAC itself produces a temporary decrease in Crs and Trs that is more significant in infants at risk for abnormal lung volume or compliance. Therefore, the sequence of performing the infant lung function parameters should be the same each time the testing is repeated with TAC as the last parameter tested at each testing session.

Original languageEnglish (US)
Pages (from-to)1567-1571
Number of pages5
JournalAmerican journal of respiratory and critical care medicine
Volume161
Issue number5
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Thoracoabdominal compression and respiratory system compliance in HIV- infected infants'. Together they form a unique fingerprint.

  • Cite this

    Platzker, A. C. G., Colin, A. A., Chen, X. C., Hiatt, P., Hunter, J., Koumbourlis, A. C., Schluchter, M. D., Ting, A., & Wohl, M. E. (2000). Thoracoabdominal compression and respiratory system compliance in HIV- infected infants. American journal of respiratory and critical care medicine, 161(5), 1567-1571. https://doi.org/10.1164/ajrccm.161.5.9902066