Thermodynamic and kinetic studies of H atom transfer from HMo(CO) 35-C5H5) to Mo(N[t-Bu]Ar) 3 and (PhCN)Mo(N[t-Bu]Ar)3: Direct insertion of benzonitrile into the Mo-H bond of HMo(N[t-Bu]Ar)3 forming (Ph(H)C=N)Mo(N[t-Bu]Ar)3

Manuel Temprado, James Eric McDonough, Arjun Mendiratta, Yi Chou Tsai, George C. Fortman, Christopher C. Cummins, Elena V. Rybak-Akimova, Carl Hoff

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Abstract

Synthetic studies are reported that show that the reaction of either H 2SnR2 (R = Ph, n-Bu) or HMo(CO)3(Cp) (1-H, Cp = η5-C5H5) with Mo(N[t-Bu]Ar)3 (2, Ar = 3,5-C6H3Me2) produce HMo(N[t-Bu]Ar)3 (2-H). The benzonitrile adduct (PhCN)Mo(N[t-Bu]Ar) 3 (2-NCPh) reacts rapidly with H2SnR2 or 1-H to produce the ketimide complex (Ph(H)C=N)Mo(N[t-Bu]Ar)3 (2-NC(H)Ph). The X-ray crystal structures of both 2-H and 2-NC(H)Ph are reported. The enthalpy of reaction of 1-H and 2 in toluene solution has been measured by solution calorimetry (ΔH = -13.1 ± 0.7 kcal mol-1) and used to estimate the Mo-H bond dissociation enthalpy (BDE) in 2-H as 62 kcal mol-1. The enthalpy of reaction of 1-H and 2-NCPh in toluene solution was determined catorimetrically as ΔH = -35.1 ± 2.1 kcal mol -1. This value combined with the enthalpy of hydrogenation of [Mo(CO)3(Cp)]2 (12) gives an estimated value of 90 kcal mol-1 for the BDE of the ketimide C-H of 2-NC(H)Ph. These data led to the prediction that formation of 2-NC(H)Ph via nitrite insertion into 2-H would be exothermic by ∼36 kcal mol-1, and this reaction was observed experimentally. Stopped flow kinetic studies of the rapid reaction of 1-H with 2-NCPh yielded ΔH = 11.9 ± 0.4 kcal mol-1, ΔS = -2.7 ± 1.2 cal K -1 mol-1. Corresponding studies with DMo(CO) 3(Cp) (1-D) showed a normal kinetic isotope effect with k H/kD ≈ 1.6, ΔH = 13.1 ± 0.4 kcal mol-1 and ΔS = 1.1 ± 1.6 cal K-1 mol-1. Spectroscopic studies of the much slower reaction of 1-H and 2 yielding 2-H and 1/212 showed generation of variable amounts of a complex proposed to be (Ar[t-Bu]N)3Mo-Mo(CO) 3(Cp) (1-2). Complex 1-2 can also be formed in small equilibrium amounts by direct reaction of excess 2 and 12. The presence of 1-2 complicates the kinetic picture; however, in the presence of excess 2, the second-order rate constant for H atom transfer from 1-H has been measured: 0.09 ± 0.01 M-1 s-1 at 1.3°C and 0.26 ± 0.04 M-1 s-1 at 17°C. Study of the rate of reaction of 1-D yielded kH/kD = 1.00 ± 0.05 consistent with an early transition state in which formation of the adduct (Ar[t-Bu]N) 3Mo⋯HMo(CO)3(Cp) is rate limiting.

Original languageEnglish
Pages (from-to)9380-9389
Number of pages10
JournalInorganic Chemistry
Volume47
Issue number20
DOIs
StatePublished - Oct 20 2008

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Carbon Monoxide
insertion
Enthalpy
Thermodynamics
Atoms
thermodynamics
Kinetics
kinetics
enthalpy
atoms
Toluene
adducts
toluene
Calorimetry
Nitrites
Isotopes
Hydrogenation
dissociation
Rate constants
Crystal structure

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Thermodynamic and kinetic studies of H atom transfer from HMo(CO) 35-C5H5) to Mo(N[t-Bu]Ar) 3 and (PhCN)Mo(N[t-Bu]Ar)3 : Direct insertion of benzonitrile into the Mo-H bond of HMo(N[t-Bu]Ar)3 forming (Ph(H)C=N)Mo(N[t-Bu]Ar)3. / Temprado, Manuel; McDonough, James Eric; Mendiratta, Arjun; Tsai, Yi Chou; Fortman, George C.; Cummins, Christopher C.; Rybak-Akimova, Elena V.; Hoff, Carl.

In: Inorganic Chemistry, Vol. 47, No. 20, 20.10.2008, p. 9380-9389.

Research output: Contribution to journalArticle

Temprado, Manuel ; McDonough, James Eric ; Mendiratta, Arjun ; Tsai, Yi Chou ; Fortman, George C. ; Cummins, Christopher C. ; Rybak-Akimova, Elena V. ; Hoff, Carl. / Thermodynamic and kinetic studies of H atom transfer from HMo(CO) 35-C5H5) to Mo(N[t-Bu]Ar) 3 and (PhCN)Mo(N[t-Bu]Ar)3 : Direct insertion of benzonitrile into the Mo-H bond of HMo(N[t-Bu]Ar)3 forming (Ph(H)C=N)Mo(N[t-Bu]Ar)3. In: Inorganic Chemistry. 2008 ; Vol. 47, No. 20. pp. 9380-9389.
@article{a7d1ec97bb0143618ea76eea8fc41f51,
title = "Thermodynamic and kinetic studies of H atom transfer from HMo(CO) 3(η5-C5H5) to Mo(N[t-Bu]Ar) 3 and (PhCN)Mo(N[t-Bu]Ar)3: Direct insertion of benzonitrile into the Mo-H bond of HMo(N[t-Bu]Ar)3 forming (Ph(H)C=N)Mo(N[t-Bu]Ar)3",
abstract = "Synthetic studies are reported that show that the reaction of either H 2SnR2 (R = Ph, n-Bu) or HMo(CO)3(Cp) (1-H, Cp = η5-C5H5) with Mo(N[t-Bu]Ar)3 (2, Ar = 3,5-C6H3Me2) produce HMo(N[t-Bu]Ar)3 (2-H). The benzonitrile adduct (PhCN)Mo(N[t-Bu]Ar) 3 (2-NCPh) reacts rapidly with H2SnR2 or 1-H to produce the ketimide complex (Ph(H)C=N)Mo(N[t-Bu]Ar)3 (2-NC(H)Ph). The X-ray crystal structures of both 2-H and 2-NC(H)Ph are reported. The enthalpy of reaction of 1-H and 2 in toluene solution has been measured by solution calorimetry (ΔH = -13.1 ± 0.7 kcal mol-1) and used to estimate the Mo-H bond dissociation enthalpy (BDE) in 2-H as 62 kcal mol-1. The enthalpy of reaction of 1-H and 2-NCPh in toluene solution was determined catorimetrically as ΔH = -35.1 ± 2.1 kcal mol -1. This value combined with the enthalpy of hydrogenation of [Mo(CO)3(Cp)]2 (12) gives an estimated value of 90 kcal mol-1 for the BDE of the ketimide C-H of 2-NC(H)Ph. These data led to the prediction that formation of 2-NC(H)Ph via nitrite insertion into 2-H would be exothermic by ∼36 kcal mol-1, and this reaction was observed experimentally. Stopped flow kinetic studies of the rapid reaction of 1-H with 2-NCPh yielded ΔH‡ = 11.9 ± 0.4 kcal mol-1, ΔS‡ = -2.7 ± 1.2 cal K -1 mol-1. Corresponding studies with DMo(CO) 3(Cp) (1-D) showed a normal kinetic isotope effect with k H/kD ≈ 1.6, ΔH‡ = 13.1 ± 0.4 kcal mol-1 and ΔS‡ = 1.1 ± 1.6 cal K-1 mol-1. Spectroscopic studies of the much slower reaction of 1-H and 2 yielding 2-H and 1/212 showed generation of variable amounts of a complex proposed to be (Ar[t-Bu]N)3Mo-Mo(CO) 3(Cp) (1-2). Complex 1-2 can also be formed in small equilibrium amounts by direct reaction of excess 2 and 12. The presence of 1-2 complicates the kinetic picture; however, in the presence of excess 2, the second-order rate constant for H atom transfer from 1-H has been measured: 0.09 ± 0.01 M-1 s-1 at 1.3°C and 0.26 ± 0.04 M-1 s-1 at 17°C. Study of the rate of reaction of 1-D yielded kH/kD = 1.00 ± 0.05 consistent with an early transition state in which formation of the adduct (Ar[t-Bu]N) 3Mo⋯HMo(CO)3(Cp) is rate limiting.",
author = "Manuel Temprado and McDonough, {James Eric} and Arjun Mendiratta and Tsai, {Yi Chou} and Fortman, {George C.} and Cummins, {Christopher C.} and Rybak-Akimova, {Elena V.} and Carl Hoff",
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doi = "10.1021/ic800945m",
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pages = "9380--9389",
journal = "Inorganic Chemistry",
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publisher = "American Chemical Society",
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TY - JOUR

T1 - Thermodynamic and kinetic studies of H atom transfer from HMo(CO) 3(η5-C5H5) to Mo(N[t-Bu]Ar) 3 and (PhCN)Mo(N[t-Bu]Ar)3

T2 - Direct insertion of benzonitrile into the Mo-H bond of HMo(N[t-Bu]Ar)3 forming (Ph(H)C=N)Mo(N[t-Bu]Ar)3

AU - Temprado, Manuel

AU - McDonough, James Eric

AU - Mendiratta, Arjun

AU - Tsai, Yi Chou

AU - Fortman, George C.

AU - Cummins, Christopher C.

AU - Rybak-Akimova, Elena V.

AU - Hoff, Carl

PY - 2008/10/20

Y1 - 2008/10/20

N2 - Synthetic studies are reported that show that the reaction of either H 2SnR2 (R = Ph, n-Bu) or HMo(CO)3(Cp) (1-H, Cp = η5-C5H5) with Mo(N[t-Bu]Ar)3 (2, Ar = 3,5-C6H3Me2) produce HMo(N[t-Bu]Ar)3 (2-H). The benzonitrile adduct (PhCN)Mo(N[t-Bu]Ar) 3 (2-NCPh) reacts rapidly with H2SnR2 or 1-H to produce the ketimide complex (Ph(H)C=N)Mo(N[t-Bu]Ar)3 (2-NC(H)Ph). The X-ray crystal structures of both 2-H and 2-NC(H)Ph are reported. The enthalpy of reaction of 1-H and 2 in toluene solution has been measured by solution calorimetry (ΔH = -13.1 ± 0.7 kcal mol-1) and used to estimate the Mo-H bond dissociation enthalpy (BDE) in 2-H as 62 kcal mol-1. The enthalpy of reaction of 1-H and 2-NCPh in toluene solution was determined catorimetrically as ΔH = -35.1 ± 2.1 kcal mol -1. This value combined with the enthalpy of hydrogenation of [Mo(CO)3(Cp)]2 (12) gives an estimated value of 90 kcal mol-1 for the BDE of the ketimide C-H of 2-NC(H)Ph. These data led to the prediction that formation of 2-NC(H)Ph via nitrite insertion into 2-H would be exothermic by ∼36 kcal mol-1, and this reaction was observed experimentally. Stopped flow kinetic studies of the rapid reaction of 1-H with 2-NCPh yielded ΔH‡ = 11.9 ± 0.4 kcal mol-1, ΔS‡ = -2.7 ± 1.2 cal K -1 mol-1. Corresponding studies with DMo(CO) 3(Cp) (1-D) showed a normal kinetic isotope effect with k H/kD ≈ 1.6, ΔH‡ = 13.1 ± 0.4 kcal mol-1 and ΔS‡ = 1.1 ± 1.6 cal K-1 mol-1. Spectroscopic studies of the much slower reaction of 1-H and 2 yielding 2-H and 1/212 showed generation of variable amounts of a complex proposed to be (Ar[t-Bu]N)3Mo-Mo(CO) 3(Cp) (1-2). Complex 1-2 can also be formed in small equilibrium amounts by direct reaction of excess 2 and 12. The presence of 1-2 complicates the kinetic picture; however, in the presence of excess 2, the second-order rate constant for H atom transfer from 1-H has been measured: 0.09 ± 0.01 M-1 s-1 at 1.3°C and 0.26 ± 0.04 M-1 s-1 at 17°C. Study of the rate of reaction of 1-D yielded kH/kD = 1.00 ± 0.05 consistent with an early transition state in which formation of the adduct (Ar[t-Bu]N) 3Mo⋯HMo(CO)3(Cp) is rate limiting.

AB - Synthetic studies are reported that show that the reaction of either H 2SnR2 (R = Ph, n-Bu) or HMo(CO)3(Cp) (1-H, Cp = η5-C5H5) with Mo(N[t-Bu]Ar)3 (2, Ar = 3,5-C6H3Me2) produce HMo(N[t-Bu]Ar)3 (2-H). The benzonitrile adduct (PhCN)Mo(N[t-Bu]Ar) 3 (2-NCPh) reacts rapidly with H2SnR2 or 1-H to produce the ketimide complex (Ph(H)C=N)Mo(N[t-Bu]Ar)3 (2-NC(H)Ph). The X-ray crystal structures of both 2-H and 2-NC(H)Ph are reported. The enthalpy of reaction of 1-H and 2 in toluene solution has been measured by solution calorimetry (ΔH = -13.1 ± 0.7 kcal mol-1) and used to estimate the Mo-H bond dissociation enthalpy (BDE) in 2-H as 62 kcal mol-1. The enthalpy of reaction of 1-H and 2-NCPh in toluene solution was determined catorimetrically as ΔH = -35.1 ± 2.1 kcal mol -1. This value combined with the enthalpy of hydrogenation of [Mo(CO)3(Cp)]2 (12) gives an estimated value of 90 kcal mol-1 for the BDE of the ketimide C-H of 2-NC(H)Ph. These data led to the prediction that formation of 2-NC(H)Ph via nitrite insertion into 2-H would be exothermic by ∼36 kcal mol-1, and this reaction was observed experimentally. Stopped flow kinetic studies of the rapid reaction of 1-H with 2-NCPh yielded ΔH‡ = 11.9 ± 0.4 kcal mol-1, ΔS‡ = -2.7 ± 1.2 cal K -1 mol-1. Corresponding studies with DMo(CO) 3(Cp) (1-D) showed a normal kinetic isotope effect with k H/kD ≈ 1.6, ΔH‡ = 13.1 ± 0.4 kcal mol-1 and ΔS‡ = 1.1 ± 1.6 cal K-1 mol-1. Spectroscopic studies of the much slower reaction of 1-H and 2 yielding 2-H and 1/212 showed generation of variable amounts of a complex proposed to be (Ar[t-Bu]N)3Mo-Mo(CO) 3(Cp) (1-2). Complex 1-2 can also be formed in small equilibrium amounts by direct reaction of excess 2 and 12. The presence of 1-2 complicates the kinetic picture; however, in the presence of excess 2, the second-order rate constant for H atom transfer from 1-H has been measured: 0.09 ± 0.01 M-1 s-1 at 1.3°C and 0.26 ± 0.04 M-1 s-1 at 17°C. Study of the rate of reaction of 1-D yielded kH/kD = 1.00 ± 0.05 consistent with an early transition state in which formation of the adduct (Ar[t-Bu]N) 3Mo⋯HMo(CO)3(Cp) is rate limiting.

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