Abstract
The goal of this study was to develop and test a new radio frequency thermal balloon system to allow longer balloon inflations at lower temperature levels than have been used with standard (laser) thermal balloon angioplasty. Radio frequency thermal capabilities were combined with perfusion balloon technology, creating a thermal-perfusion balloon catheter system for prolonged thermal inflations. Twenty-five dogs underwent thermal-perfusion angioplasty at 37°, 60°, or 80° C for 1.5, 5, or 15 minutes with angiographic and morphologic assessments at 24 hours (n = 17) or 4-6 weeks later (n = 8). Treated segments and side branches remained patent. No coronary spasm, occlusive thrombus, or ischemic myocardial infarction occurred. Histologic extent of thermal injury in treated segments was proportional to treatment duration. Thus the thermal-perfusion balloon angioplasty system may be safely applied in canine technologies provides prolonged treatment duration at moderate temperatures without excessive tissue damage.
| Original language | English |
|---|---|
| Pages (from-to) | 226-233 |
| Number of pages | 8 |
| Journal | American Heart Journal |
| Volume | 125 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Thermal-perfusion balloon coronary angioplasty : In vivo evaluation. / Buller, Christopher E.; Culp, Stephen C.; Sketch, Michael H.; Phillips, Harry R.; Virmani, Renu; Stack, Richard S.
In: American Heart Journal, Vol. 125, No. 1, 01.01.1993, p. 226-233.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thermal-perfusion balloon coronary angioplasty
T2 - In vivo evaluation
AU - Buller, Christopher E.
AU - Culp, Stephen C.
AU - Sketch, Michael H.
AU - Phillips, Harry R.
AU - Virmani, Renu
AU - Stack, Richard S.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - The goal of this study was to develop and test a new radio frequency thermal balloon system to allow longer balloon inflations at lower temperature levels than have been used with standard (laser) thermal balloon angioplasty. Radio frequency thermal capabilities were combined with perfusion balloon technology, creating a thermal-perfusion balloon catheter system for prolonged thermal inflations. Twenty-five dogs underwent thermal-perfusion angioplasty at 37°, 60°, or 80° C for 1.5, 5, or 15 minutes with angiographic and morphologic assessments at 24 hours (n = 17) or 4-6 weeks later (n = 8). Treated segments and side branches remained patent. No coronary spasm, occlusive thrombus, or ischemic myocardial infarction occurred. Histologic extent of thermal injury in treated segments was proportional to treatment duration. Thus the thermal-perfusion balloon angioplasty system may be safely applied in canine technologies provides prolonged treatment duration at moderate temperatures without excessive tissue damage.
AB - The goal of this study was to develop and test a new radio frequency thermal balloon system to allow longer balloon inflations at lower temperature levels than have been used with standard (laser) thermal balloon angioplasty. Radio frequency thermal capabilities were combined with perfusion balloon technology, creating a thermal-perfusion balloon catheter system for prolonged thermal inflations. Twenty-five dogs underwent thermal-perfusion angioplasty at 37°, 60°, or 80° C for 1.5, 5, or 15 minutes with angiographic and morphologic assessments at 24 hours (n = 17) or 4-6 weeks later (n = 8). Treated segments and side branches remained patent. No coronary spasm, occlusive thrombus, or ischemic myocardial infarction occurred. Histologic extent of thermal injury in treated segments was proportional to treatment duration. Thus the thermal-perfusion balloon angioplasty system may be safely applied in canine technologies provides prolonged treatment duration at moderate temperatures without excessive tissue damage.
UR - http://www.scopus.com/inward/record.url?scp=0027509395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027509395&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(93)90079-O
DO - 10.1016/0002-8703(93)90079-O
M3 - Article
C2 - 8417522
AN - SCOPUS:0027509395
VL - 125
SP - 226
EP - 233
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 1
ER -