Thermal energy effects on articular cartilage

A multidisciplinary evaluation

Lee Kaplan, John M. Ersthausen, Dan S. Ionescu, Rebecca K. Studer, James P. Bradley, Constance Chu, Freddie H. Fu, Daniel L. Farkas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Partial thickness articular cartilage lesions are commonly encountered in orthopedic surgery. These lesions do not have the ability to heal by themselves, due to lack of vascular supply. Several types of treatment have addressed this problem, including mechanical debridement and thermal chondroplasty. The goal of these treatments is to provide a smooth cartilage surface and prevent propagation of the lesions. Early thermal chondroplasty was performed using lasers, and yielded very mixed results, including severe damage to the cartilage, due to poor control of the induced thermal effects. This led to the development (including commercial) of probes using radiofrequency to generate the thermal effects desired for chondroplasty. Similar concerns over the quantitative aspects and control ability of the induced thermal effects in these treatments led us to test the whole range of complex issues and parameters involved. Our investigations are designed to simultaneously evaluate clinical conditions, instrument variables for existing radiofrequency probes (pressure, speed, distance, dose) as well as the associated basic science issues such as damage temperature and controllability (down to the subcellular level), damage geometry, and effects of surrounding conditions (medium, temperature, flow, pressure). The overall goals of this work are (1) to establish whether thermal chondroplasty can be used in a safe and efficacious manner, and (2) provide a prescription for multi-variable optimization of the way treatments are delivered, based on quantitative analysis. The methods used form an interdisciplinary set, to include precise mechanical actuation, high accuracy temperature and temperature gradient control and measurement, advanced imaging approaches and mathematical modeling.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsD.L. Farkas, R.C. Leif
Pages11-23
Number of pages13
Volume4622
DOIs
StatePublished - 2002
Externally publishedYes
EventOptical Diagnostics of Living Cells V - San Jose, CA, United States
Duration: Jan 23 2002Jan 25 2002

Other

OtherOptical Diagnostics of Living Cells V
CountryUnited States
CitySan Jose, CA
Period1/23/021/25/02

Fingerprint

cartilage
Cartilage
Thermal energy
thermal energy
Thermal effects
lesions
temperature effects
evaluation
damage
Orthopedics
Controllability
orthopedics
Thermal gradients
Temperature
Surgery
controllability
pressure sensors
actuation
surgery
quantitative analysis

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Kaplan, L., Ersthausen, J. M., Ionescu, D. S., Studer, R. K., Bradley, J. P., Chu, C., ... Farkas, D. L. (2002). Thermal energy effects on articular cartilage: A multidisciplinary evaluation. In D. L. Farkas, & R. C. Leif (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4622, pp. 11-23) https://doi.org/10.1117/12.468358

Thermal energy effects on articular cartilage : A multidisciplinary evaluation. / Kaplan, Lee; Ersthausen, John M.; Ionescu, Dan S.; Studer, Rebecca K.; Bradley, James P.; Chu, Constance; Fu, Freddie H.; Farkas, Daniel L.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / D.L. Farkas; R.C. Leif. Vol. 4622 2002. p. 11-23.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kaplan, L, Ersthausen, JM, Ionescu, DS, Studer, RK, Bradley, JP, Chu, C, Fu, FH & Farkas, DL 2002, Thermal energy effects on articular cartilage: A multidisciplinary evaluation. in DL Farkas & RC Leif (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4622, pp. 11-23, Optical Diagnostics of Living Cells V, San Jose, CA, United States, 1/23/02. https://doi.org/10.1117/12.468358
Kaplan L, Ersthausen JM, Ionescu DS, Studer RK, Bradley JP, Chu C et al. Thermal energy effects on articular cartilage: A multidisciplinary evaluation. In Farkas DL, Leif RC, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4622. 2002. p. 11-23 https://doi.org/10.1117/12.468358
Kaplan, Lee ; Ersthausen, John M. ; Ionescu, Dan S. ; Studer, Rebecca K. ; Bradley, James P. ; Chu, Constance ; Fu, Freddie H. ; Farkas, Daniel L. / Thermal energy effects on articular cartilage : A multidisciplinary evaluation. Proceedings of SPIE - The International Society for Optical Engineering. editor / D.L. Farkas ; R.C. Leif. Vol. 4622 2002. pp. 11-23
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