Therapy resistance, cancer stem cells and ECM in cancer: The matrix reloaded

Kousik Kesh, Vineet K. Gupta, Brittany Durden, Vanessa Garrido, Beatriz Mateo-Victoriano, Shweta P. Lavania, Sulagna Banerjee

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

The extracellular matrix (ECM) has remained an enigmatic component of the tumor microenvironment. It drives metastasis via its interaction with the integrin signaling pathway, contributes to tumor progression and confers therapy resistance by providing a physical barrier around the tumor. The complexity of the ECM lies in its heterogeneous composition and complex glycosylation that can provide a support matrix as well as trigger oncogenic signaling pathways by interacting with the tumor cells. In this review, we attempt to dissect the role of the ECM in enriching for the treatment refractory cancer stem cell population and how it may be involved in regulating their metabolic needs. Additionally, we discuss how the ECM is instrumental in remodeling the tumor immune microenvironment and the potential ways to target this component in order to develop a viable therapy.

Original languageEnglish (US)
Article number3067
Pages (from-to)1-17
Number of pages17
JournalCancers
Volume12
Issue number10
DOIs
StatePublished - Oct 2020

Keywords

  • Cancer metabolism
  • Cancer stem cells
  • Extra cellular matrix

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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