Fungal infections can involve various regions of the eye and periocular tissues, including the lacrimal apparatus, conjunctiva, eyelids, and bony orbit. The two most common sites for fungal infections of the eye are the cornea and retina or vitreous. Successful medical treatment of fungal keratitis and endophthalmitis depends not only on the spectrum of antifungal activity of the particular drug but also on the pharmacokinetic properties of the agent. This article reviews the antifungal agents currently available and under development for use in therapy of ocular fungal infections.
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