Therapy of Ischemic Cerebral Vascular Disease Due to Atherothrombosis

J. Philip Kistler, Allan H. Ropper, Roberto C. Heros

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations


Preventive therapy of atherothrombotic ischemic stroke has three goals: to prevent stroke by reducing risk factors, thus preventing the pathologic process; to prevent initial or recurrent stroke by removing the underlying pathologic process - for example, by performing a carotid endarterectomy; and to ameliorate secondary brain damage by maintaining adequate perfusion to marginally ischemic areas and perhaps by reducing edema formation. Except for the elimination of risk factors, all aspects of therapy are controversial. Published proof of any given therapeutic approach is lacking; hence, current therapy is largely empirical and based on each institution's knowledge of the risks associated with its own diagnostic procedures and therapies.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalNew England Journal of Medicine
Issue number1
StatePublished - Jul 5 1984
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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